Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.
J Rheumatol. 2010 Feb;37(2):410-6. doi: 10.3899/jrheum.090736. Epub 2009 Dec 23.
Studies have shown that obesity is associated with an increase in serum uric acid; and few data are available on the relationship between changes in measures of obesity and changes in uric acid concentrations. We investigated the relationship among percentage changes in waist circumference (%dWC), body mass index (%dBMI), and serum uric acid (%dUA).
The data of 3153 individuals [1968 men, 1185 women (536 premenopausal, 649 postmenopausal)] who underwent general health screening over a 2-year period and were not taking antihyperuricemic medication were analyzed.
Stepwise multiple regression analysis showed that %dBMI was associated positively with %dUA in postmenopausal women and men, and the association retained statistical significance after adjustment for changes in blood pressure and in renal function. Association between %dBMI and %dUA was not significant in premenopausal women. In men, %dWC was a predicting factor for %dUA, although it did not remain significant when %dBMI was used as a covariate in the statistical model. Multivariate logistic regression analysis showed that the odds ratio of the association between the lowest %dBMI quartile (%dBMI < -1.86) and the lowest %dUA quartile (%dUA < -7.41) was 2.04 (95% CI 1.35-3.07) in postmenopausal women and 1.46 (95% CI 1.14-1.86) in men.
Weight loss may represent an effective nonmedical strategy for reducing serum UA levels, especially in postmenopausal women and men.
研究表明肥胖与血清尿酸升高有关；关于肥胖测量指标的变化与尿酸浓度变化之间的关系，数据有限。我们研究了腰围百分比变化（%dWC）、体重指数（%dBMI）和血清尿酸（%dUA）之间的关系。
分析了在 2 年内接受一般健康检查且未服用降尿酸药物的 3153 名个体[1968 名男性，1185 名女性（536 名绝经前，649 名绝经后）]的数据。
逐步多元回归分析显示，绝经后妇女和男性的 %dBMI 与 %dUA 呈正相关，且在调整血压和肾功能变化后仍具有统计学意义。绝经前妇女中 %dBMI 与 %dUA 之间的相关性不显著。在男性中，%dWC 是 %dUA 的预测因素，但在统计学模型中使用 %dBMI 作为协变量时，其相关性不再显著。多元逻辑回归分析显示，绝经后妇女中最低 %dBMI 四分位数（%dBMI <-1.86）和最低 %dUA 四分位数（%dUA <-7.41）之间关联的优势比为 2.04（95%CI 1.35-3.07），男性为 1.46（95%CI 1.14-1.86）。
减肥可能是降低血清 UA 水平的有效非医学策略，尤其是在绝经后妇女和男性中。
