Stuyven E, Verdonck F, Van Hoek I, Daminet S, Duchateau L, Remon J P, Goddeeris B M, Cox E
Laboratory of Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke B-9820, Belgium.
Clin Vaccine Immunol. 2010 Feb;17(2):281-5. doi: 10.1128/CVI.00344-09. Epub 2009 Dec 23.
The effect of oral administration of beta-1,3/1,6-glucans from Saccharomyces cerevisiae on humoral immunity in domestic dogs is not known. In this study, 15 beagle dogs were orally given MacroGard tablets, which contain 150 mg of this beta-glucan, daily for 4 weeks. At the end of this period, the total serum immunoglobulin A (IgA) level decreased significantly in the group treated with the glucan compared to that in the control group as well as compared to the concentrations before supplementation. In contrast, the total serum IgM level rose significantly, whereas no effect on the IgG level occurred. Similar changes were seen in Bordetella-specific IgA and IgM titers following vaccination during the supplementation period. The IgA concentration also became significantly lower in the saliva and tears of the glucan group than in the placebo group. The effects disappeared 1 week after the cessation of the supplementation. In conclusion, the results showed a temporary change in the isotype profile during glucan supplementation.
口服来自酿酒酵母的β-1,3/1,6-葡聚糖对家犬体液免疫的影响尚不清楚。在本研究中，15只比格犬每天口服含150毫克这种β-葡聚糖的MacroGard片剂，持续4周。在此期间结束时，与对照组相比以及与补充前的浓度相比，用葡聚糖治疗的组中血清总免疫球蛋白A（IgA）水平显著降低。相反，血清总IgM水平显著升高，而对IgG水平没有影响。在补充期间接种疫苗后，博德特氏菌特异性IgA和IgM滴度也出现了类似变化。葡聚糖组唾液和泪液中的IgA浓度也比安慰剂组显著降低。补充停止1周后，这些影响消失。总之，结果表明在葡聚糖补充期间同种型谱发生了暂时变化。
