Department of General, Visceral and Cancer Surgery, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
Anticancer Res. 2009 Nov;29(11):4451-5.
PIM kinases are mediators of cytokine signalling pathways in hematopoietic cells and contribute to the progression of certain types of leukemia and solid tumor. Here the prognostic impact of proto-oncogene PIM-1 was analyzed in gastric carcinoma.
Cancer tissues of 117 patients with potentially curative (R0) resections for gastric cancer were immunohistochemically stained for PIM-1.
Cytoplasmic immunoreactivity for PIM-1 in tumor (46%) was higher (p=0.003) compared to that in gastric glands (16%) and foveolae (1%). PIM-1 immunoreactivity in gastric carcinoma correlated with tumor grading (p<0.05) and Laurén category (p<0.02). Overexpression of PIM-1 in gastric glands (p<0.001) was associated with formation of lymph node metastases (p=0.035) and survival (p=0.04). Multivariate analysis of PIM-1 expression in gastric glands confirmed its association with prognosis.
Up-regulation of PIM-1 oncogene might be a tumor marker for gastric cancer. The correlation of PIM-1 overexpression in gastric glands with formation of lymph node metastases and survival proposes a prognostic role in gastric cancer.
PIM 激酶是造血细胞中细胞因子信号通路的介质，有助于某些类型的白血病和实体瘤的进展。在此，分析了原癌基因 PIM-1 在胃癌中的预后影响。
对 117 例接受潜在根治性（R0）胃切除术的胃癌患者的癌组织进行了 PIM-1 的免疫组织化学染色。
肿瘤中 PIM-1 的细胞质免疫反应性（46%）高于胃腺（16%）和小凹（1%）（p=0.003）。胃癌中 PIM-1 的免疫反应性与肿瘤分级（p<0.05）和 Laurén 分类（p<0.02）相关。胃腺中 PIM-1 的过表达（p<0.001）与淋巴结转移的形成（p=0.035）和生存（p=0.04）相关。胃腺中 PIM-1 表达的多变量分析证实了其与预后的相关性。
PIM-1 癌基因的上调可能是胃癌的肿瘤标志物。胃腺中 PIM-1 过表达与淋巴结转移和生存的相关性提示其在胃癌中的预后作用。
