Sardaş S, Gök S, Karakaya A E
Department of Toxicology, Gazi University, Faculty of Pharmacy, Ankara, Turkey.
Toxicol Lett. 1991 Mar;55(3):311-5. doi: 10.1016/0378-4274(91)90012-u.
The effects of handling antineoplastic drugs were examined in a group of 23 nurses working in the hematology and oncology departments of different university hospitals in Ankara and in a group of 50 unexposed controls. The cytogenetic repercussions of exposure were assessed by examining sister chromatid exchanges (SCEs) in circulating lymphocytes which result from the breakage and rejoining of DNA at apparently homologous sites on the 2 chromatids of a single chromosome. A significant increased frequency of SCE is observed in nurses in daily contact with antineoplastics (n = 23, mean SCEs/cell +/- SE 6.5 +/- 0.2) as compared to a group of controls (n = 50, mean SCEs/cell 5.2 +/- 0.2). The nurses who smoked also had a higher SCE frequency (n = 15, mean SCEs/cell 7.0 +/- 0.3) than non-smokers, (n = 8, mean SCEs/cell 5.5 +/- 0.3). A significant increase (P less than 0.001) in the mean number of SCE was found for non-smoking nurses as compared to non-smoking controls (n = 27, mean SCEs/cell 4.1 +/- 0.2).
在安卡拉不同大学医院的血液学和肿瘤学部门工作的23名护士以及50名未接触过抗肿瘤药物的对照人员组成的一组中，研究了处理抗肿瘤药物的影响。通过检查循环淋巴细胞中的姐妹染色单体交换（SCE）来评估接触的细胞遗传学影响，SCE是由单条染色体的两条染色单体上明显同源位点的DNA断裂和重新连接产生的。与一组对照人员（n = 50，平均每个细胞的SCE数为5.2 +/- 0.2）相比，每天接触抗肿瘤药物的护士（n = 23，平均每个细胞的SCE数+/-标准误为6.5 +/- 0.2）中观察到SCE频率显著增加。吸烟的护士（n = 15，平均每个细胞的SCE数为7.0 +/- 0.3）的SCE频率也高于不吸烟的护士（n = 8，平均每个细胞的SCE数为5.5 +/- 0.3）。与不吸烟的对照人员（n = 27，平均每个细胞的SCE数为4.1 +/- 0.2）相比，不吸烟的护士的SCE平均数显著增加（P小于0.001）。
