接触细胞毒性药物的护士淋巴细胞中姐妹染色单体交换频率增加。

Increased sister chromatid exchange frequencies in lymphocytes of nurses handling cytostatic drugs.

作者信息

Norppa H, Sorsa M, Vainio H, Gröhn P, Heinonen E, Holsti L, Nordman E

出版信息

Scand J Work Environ Health. 1980 Dec;6(4):299-301. doi: 10.5271/sjweh.2605.

Abstract

In oncology units, personnel handling chemotherapeutic drugs may occasionally be exposed to small amounts of genotoxic agents. This exposure was obviously the cause of the increased frequencies of sister chromatid exchange (SCE) observed in nurses in daily contact with cytostatics (N = 20, mean SCEs/cell +/- SE 9.4 +/- 0.3) as compared to a group of office workers (N = 10, mean SCEs/cell 8.1 +/- 0.3). The oncology nurses also had a higher SCE frequency than other hospital nurses (N = 10, mean SCEs/cell 8.7 +/- 0.2), but this difference was not statistically significant. The SCEs of patients under chemotherapy were about five times higher (mean SCEs/cell 36.8 +/- 0.6) than those of healthy subjects.

摘要

在肿瘤科室，处理化疗药物的人员偶尔可能会接触到少量的基因毒性剂。与一组办公室职员（N = 10，平均每个细胞的姐妹染色单体交换数为8.1 ± 0.3）相比，日常接触细胞抑制剂的护士（N = 20，平均每个细胞的姐妹染色单体交换数±标准误为9.4 ± 0.3）中观察到的姐妹染色单体交换（SCE）频率增加显然是这种接触所致。肿瘤科室护士的SCE频率也高于其他医院护士（N = 10，平均每个细胞的姐妹染色单体交换数为8.7 ± 0.2），但这种差异无统计学意义。接受化疗患者的SCE约比健康受试者高五倍（平均每个细胞的姐妹染色单体交换数为36.8 ± 0.6）。