苦瓜中的新葫芦烷三萜和甾体糖苷。
New cucurbitane triterpenoids and steroidal glycoside from Momordica charantia.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204 Yunnan, China.
出版信息
Molecules. 2009 Nov 25;14(12):4804-13. doi: 10.3390/molecules14124804.
Three new cucurbitane triterpenoids 1-3 and one new steroidal glycoside 4, were isolated together with ten known compounds from Momordica charantia. The structures of new compounds were determined to be 19(R)-n-butanoxy-5 beta,19-epoxycucurbita-6,23-diene-3beta,25-diol 3-O-beta-glucopyranoside (1), 23-O-beta-allopyranosylecucurbita-5,24-dien-7 alpha,3beta,22(R),23(S)-tetraol 3-O-beta-allopyranoside. (2), 23(R),24(S),25-trihydroxycucurbit-5-ene 3-O-{[beta-glucopyranosyl(1-->6)]-O-beta-glucopyranosyl}-25-O-beta-glucopyranoside (3), and 24(R)-stigmastan-3beta,5 alpha,6 beta-triol-25-ene 3-O-beta-glucopyranoside (4), respectively. Their structures were elucidated by the combination of mass spectrometry (MS), one and two-dimensional NMR experiments and chemical reactions.
从苦瓜中分离得到三个新的葫芦烷三萜 1-3 和一个新的甾体糖苷 4，以及十个已知化合物。新化合物的结构被确定为 19(R)-正丁氧基-5β，19-环氧葫芦烷-6，23-二烯-3β，25-二醇 3-O-β-吡喃葡萄糖苷（1），23-O-β-吡喃阿拉伯糖苷基-葫芦烷-5,24-二烯-7α，3β，22（R），23（S）-四醇 3-O-β-吡喃阿拉伯糖苷（2），23（R），24（S），25-三羟基葫芦烷-5-烯 3-O-[[β-吡喃葡萄糖基（1->6）]-O-β-吡喃葡萄糖基]-25-O-β-吡喃葡萄糖苷（3），和 24（R）-豆甾烷-3β，5α，6β-三醇-25-烯 3-O-β-吡喃葡萄糖苷（4）。通过质谱（MS）、一维和二维 NMR 实验以及化学反应的组合，确定了它们的结构。
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