State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204 Yunnan, China.
Molecules. 2009 Nov 25;14(12):4804-13. doi: 10.3390/molecules14124804.
Three new cucurbitane triterpenoids 1-3 and one new steroidal glycoside 4, were isolated together with ten known compounds from Momordica charantia. The structures of new compounds were determined to be 19(R)-n-butanoxy-5 beta,19-epoxycucurbita-6,23-diene-3beta,25-diol 3-O-beta-glucopyranoside (1), 23-O-beta-allopyranosylecucurbita-5,24-dien-7 alpha,3beta,22(R),23(S)-tetraol 3-O-beta-allopyranoside. (2), 23(R),24(S),25-trihydroxycucurbit-5-ene 3-O-{[beta-glucopyranosyl(1-->6)]-O-beta-glucopyranosyl}-25-O-beta-glucopyranoside (3), and 24(R)-stigmastan-3beta,5 alpha,6 beta-triol-25-ene 3-O-beta-glucopyranoside (4), respectively. Their structures were elucidated by the combination of mass spectrometry (MS), one and two-dimensional NMR experiments and chemical reactions.
从苦瓜中分离得到三个新的葫芦烷三萜 1-3 和一个新的甾体糖苷 4，以及十个已知化合物。新化合物的结构被确定为 19(R)-正丁氧基-5β，19-环氧葫芦烷-6，23-二烯-3β，25-二醇 3-O-β-吡喃葡萄糖苷（1），23-O-β-吡喃阿拉伯糖苷基-葫芦烷-5,24-二烯-7α，3β，22（R），23（S）-四醇 3-O-β-吡喃阿拉伯糖苷（2），23（R），24（S），25-三羟基葫芦烷-5-烯 3-O-[[β-吡喃葡萄糖基（1->6）]-O-β-吡喃葡萄糖基]-25-O-β-吡喃葡萄糖苷（3），和 24（R）-豆甾烷-3β，5α，6β-三醇-25-烯 3-O-β-吡喃葡萄糖苷（4）。通过质谱（MS）、一维和二维 NMR 实验以及化学反应的组合，确定了它们的结构。
