Department of Radiology, Venetian Oncological Institute (IOV), IRCCS, Padua, Italy.
Eur Radiol. 2010 Jul;20(7):1545-53. doi: 10.1007/s00330-009-1699-5. Epub 2009 Dec 22.
To compare the clinical performance of digital breast tomosynthesis (DBT) with that of full-field digital mammography (FFDM) in a diagnostic population.
The study enrolled 200 consenting women who had at least one breast lesion discovered by mammography and/or ultrasound classified as doubtful or suspicious or probably malignant. They underwent tomosynthesis in one view [mediolateral oblique (MLO)] of both breasts at a dose comparable to that of standard screen-film mammography in two views [craniocaudal (CC) and MLO]. Images were rated by six breast radiologists using the BIRADS score. Ratings were compared with the truth established according to the standard of care and a multiple-reader multiple-case (MRMC) receiver-operating characteristic (ROC) analysis was performed. Clinical performance of DBT compared with that of FFDM was evaluated in terms of the difference between areas under ROC curves (AUCs) for BIRADS scores.
Overall clinical performance with DBT and FFDM for malignant versus all other cases was not significantly different (AUCs 0.851 vs 0.836, p = 0.645). The lower limit of the 95% CI or the difference between DBT and FFDM AUCs was -4.9%.
Clinical performance of tomosynthesis in one view at the same total dose as standard screen-film mammography is not inferior to digital mammography in two views.
比较数字乳腺断层合成（DBT）与全数字化乳腺摄影（FFDM）在诊断人群中的临床性能。
这项研究纳入了 200 名自愿参加的女性，她们的至少一个乳房病变通过乳腺摄影和/或超声检查被归类为可疑或疑似恶性或可能恶性。她们接受了断层合成检查，每只乳房进行一次视图（外侧斜位[MLO]），剂量与标准屏片乳腺摄影的两个视图（头尾位[CC]和 MLO）相当。由六名乳腺放射科医生使用 BIRADS 评分对图像进行评分。评分与根据护理标准确定的真实情况进行比较，并进行了多读者多病例（MRMC）接收器操作特征（ROC）分析。通过比较 BIRADS 评分的 ROC 曲线下面积（AUCs），评估 DBT 与 FFDM 的临床性能差异。
DBT 和 FFDM 对恶性与所有其他病例的总体临床性能无显著差异（AUCs 分别为 0.851 和 0.836，p = 0.645）。DBT 和 FFDM AUC 之间差异的 95%CI 的下限或下限为-4.9%。
在与标准屏片乳腺摄影相同的总剂量下，单次视图的断层合成术的临床性能并不逊于双视图的数字乳腺摄影。
