Center for Child and Adolescent Health Policy, Massachusetts General Hospital, Boston, MA, USA.
J Autism Dev Disord. 2010 Jun;40(6):721-9. doi: 10.1007/s10803-009-0921-2.
We examined data collected as a part of the Autism Treatment Network, a group of 15 autism centers across the United States and Canada. Mean Health-Related Quality of Life (HRQoL) scores of the 286 children assessed were significantly lower than those of healthy populations (according to published norms). When compared to normative data from children with chronic conditions, children with ASD demonstrated worse HRQoL for total, psychosocial, emotional and social functioning, but did not demonstrate differing scores for physical and school functioning. HRQoL was not consistently related to ASD diagnosis or intellectual ability. However, it was consistently related to internalizing and externalizing problems as well as repetitive behaviors, social responsiveness, and adaptive behaviors. Associations among HRQoL and behavioral characteristics suggest that treatments aimed at improvements in these behaviors may improve HRQoL.
我们研究了自闭症治疗网络（Autism Treatment Network）收集的数据，该网络由美国和加拿大的 15 个自闭症中心组成。接受评估的 286 名儿童的平均健康相关生活质量（Health-Related Quality of Life，HRQoL）评分明显低于健康人群（根据已发表的标准）。与患有慢性疾病的儿童的规范数据相比，患有 ASD 的儿童在总体、心理社会、情绪和社会功能方面的 HRQoL 更差，但在身体和学业功能方面的得分没有差异。HRQoL 与 ASD 诊断或智力能力并不一致相关。然而，它与内化和外化问题以及重复行为、社交反应和适应行为一致相关。HRQoL 和行为特征之间的关联表明，旨在改善这些行为的治疗方法可能会改善 HRQoL。
