Cray Carolyn, Zaias Julia, Altman Norman H
Division of Comparative Pathology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Comp Med. 2009 Dec;59(6):517-26.
The acute phase response is a complex systemic early-defense system activated by trauma, infection, stress, neoplasia, and inflammation. Although nonspecific, it serves as a core of the innate immune response involving physical and molecular barriers and responses that serve to prevent infection, clear potential pathogens, initiate inflammatory processes, and contribute to resolution and the healing process. Acute phase proteins, an integral part of the acute phase response, have been a focus of many applications in human diagnostic medicine and recently have been identified in common animal species. Potential applications to diagnosis, prognosis, assessment of animal health, and laboratory animal welfare are readily apparent.
急性期反应是一种由创伤、感染、应激、肿瘤和炎症激活的复杂的全身早期防御系统。尽管是非特异性的，但它是先天免疫反应的核心，涉及物理和分子屏障以及旨在预防感染、清除潜在病原体、启动炎症过程并促进疾病消退和愈合过程的反应。急性期蛋白是急性期反应的一个组成部分，一直是人类诊断医学中许多应用的重点，最近在常见动物物种中也已被识别出来。其在诊断、预后评估、动物健康评估以及实验动物福利方面的潜在应用显而易见。
