Tecles Fernando, Caldín Marco, Zanella Anna, Membiela Francisco, Tvarijonaviciute Asta, Subiela Silvia Martínez, Cerón José Joaquín
Animal Medicine and Surgery Department, School of Veterinary Medicine, University of Murcia, Campus Espinardo s/n 30100 Espinardo, Murcia, Spain.
J Vet Diagn Invest. 2009 Mar;21(2):214-9. doi: 10.1177/104063870902100206.
Acute phase proteins (APPs) are proteins whose concentrations in serum change after any inflammatory stimulus or tissue damage. The aim of the current study was to evaluate 3 positive APPs (C-reactive protein, serum amyloid A, and haptoglobin) and 1 negative APP (albumin) in female dogs with mammary neoplasia. Acute phase proteins were studied in 70 female dogs aged 8-12 years in the following groups: healthy (n = 10); mammary tumors in stages I (n = 19), II (n = 5), III (n = 6), IV (n = 5), and V (n = 7); and with mammary neoplasia plus a concomitant disease (n = 18). In animals with mammary neoplasia, significant increases of positive APPs were only detected in those that had metastasis or a neoplasm with a diameter greater than 5 cm and ulceration. Dogs with mammary neoplasia and a concomitant disease also had high C-reactive protein concentrations. Albumin concentration was decreased in animals with metastasis and with a concomitant disease. The results of the present study indicate that the acute phase response could be stimulated in female dogs with mammary gland tumors because of different factors, such as metastasis, large size of the primary mass, and ulceration or secondary inflammation of the neoplasm.
急性期蛋白（APPs）是指血清中浓度在受到任何炎症刺激或组织损伤后会发生变化的蛋白质。本研究的目的是评估患有乳腺肿瘤的雌性犬的3种阳性APP（C反应蛋白、血清淀粉样蛋白A和触珠蛋白）和1种阴性APP（白蛋白）。对70只年龄在8至12岁的雌性犬进行了急性期蛋白研究，分为以下几组：健康组（n = 10）；I期乳腺肿瘤组（n = 19）、II期（n = 5）、III期（n = 6）、IV期（n = 5）和V期（n = 7）；以及患有乳腺肿瘤并伴有其他疾病的组（n = 18）。在患有乳腺肿瘤的动物中，仅在那些发生转移或肿瘤直径大于5 cm且有溃疡的动物中检测到阳性APPs显著增加。患有乳腺肿瘤并伴有其他疾病的犬C反应蛋白浓度也很高。发生转移和伴有其他疾病的动物白蛋白浓度降低。本研究结果表明，由于转移、原发肿块较大、肿瘤溃疡或继发炎症等不同因素，患有乳腺肿瘤的雌性犬可能会激发急性期反应。
