Dong Xiao-Yu
College of Life and Health, Dalian University, Dalian 116622, China.
J Fungi (Basel). 2023 Apr 28;9(5):524. doi: 10.3390/jof9050524.
Regulating calcium ion (Ca) channels to improve the cell cycle and metabolism is a promising technology, ensuring increased cell growth, differentiation, and/or productivity. In this regard, the composition and structure of Ca channels play a vital role in controlling the gating states. In this review, , as a model eukaryotic organism and an essential industrial microorganism, was used to discuss the effect of its type, composition, structure, and gating mechanism on the activity of Ca channels. Furthermore, the advances in the application of Ca channels in pharmacology, tissue engineering, and biochemical engineering are summarized, with a special focus on exploring the receptor site of Ca channels for new drug design strategies and different therapeutic uses, targeting Ca channels to produce functional replacement tissues, creating favorable conditions for tissue regeneration, and regulating Ca channels to enhance biotransformation efficiency.
调节钙离子（Ca）通道以改善细胞周期和新陈代谢是一项很有前景的技术，可确保细胞生长、分化和/或生产力提高。在这方面，Ca通道的组成和结构在控制门控状态中起着至关重要的作用。在本综述中， 作为一种模式真核生物和重要的工业微生物，被用于讨论其类型、组成、结构和门控机制对Ca通道活性的影响。此外，还总结了Ca通道在药理学、组织工程和生物化学工程中的应用进展，特别关注探索Ca通道的受体位点以用于新药设计策略和不同的治疗用途，靶向Ca通道以产生功能性替代组织，为组织再生创造有利条件，以及调节Ca通道以提高生物转化效率。
