Department of Pediatrics, Tung's Taichung MetroHarbor Hospital, Taichung, Taiwan.
Biochem Biophys Res Commun. 2010 Jan 15;391(3):1537-42. doi: 10.1016/j.bbrc.2009.12.119. Epub 2009 Dec 28.
Inflammation is involved in cholestasis-induced hepatic damage. Stearic acid has been shown to possess anti-inflammatory potential. We assessed whether stearic acid has protective effects against cholestasis-related liver damage. Cholestasis was produced by bile duct ligation (BDL) in male Sprague-Dawley rats for 3weeks. Daily administration of stearic acid was started 2weeks before injury and lasted for 5weeks. In comparison with the control group, the BDL group showed hepatic damage as evidenced by elevation in serum biochemicals, ductular reaction, fibrosis, and inflammation. These pathophysiological changes were attenuated by chronic stearic acid supplementation. The anti-fibrotic effect of stearic acid was accompanied by reductions in alpha-smooth muscle actin-positive matrix-producing cells and critical fibrogenic cytokine transforming growth factor beta-1 production. Stearic acid also attenuated BDL-induced leukocyte accumulation and NF-kappaB activation. The data indicate that stearic acid attenuates BDL-induced cholestatic liver injury. The hepatoprotective effect of stearic acid is associated with anti-inflammatory potential.
炎症参与胆汗淤积性肝损伤。硬脂酸具有抗炎作用。我们评估了硬脂酸对胆汁淤积相关肝损伤是否具有保护作用。通过胆管结扎（BDL）在雄性 Sprague-Dawley 大鼠中产生胆汁淤积，持续 3 周。硬脂酸的每日给药在损伤前 2 周开始，并持续 5 周。与对照组相比，BDL 组表现出肝损伤，血清生化指标升高，胆管反应、纤维化和炎症。慢性硬脂酸补充可减轻这些病理生理变化。硬脂酸的抗纤维化作用伴随着 alpha-平滑肌肌动蛋白阳性基质产生细胞和关键纤维化细胞因子转化生长因子-β1 产生的减少。硬脂酸还减轻 BDL 诱导的白细胞积聚和 NF-kappaB 激活。数据表明，硬脂酸可减轻 BDL 诱导的胆汁淤积性肝损伤。硬脂酸的肝保护作用与其抗炎作用有关。
