Harris C P, Alderson K, Nebeker J, Holds J B, Anderson R L
Department of Neurology, University of Utah School of Medicine, Salt Lake City.
Arch Ophthalmol. 1991 Mar;109(3):393-5. doi: 10.1001/archopht.1991.01080030095046.
To evaluate muscle histologic features in humans following therapeutic botulinum toxin injections, we studied orbicularis oculi from 11 patients with blepharospasm; nine had previously received botulinum toxin injections and two had not. All muscles had comparable variability in muscle fiber diameter, with no necrosis, inflammation, denervation, or consistent alterations in muscle fiber internal architecture. Botulinum toxin produces no persistent histologic changes in human muscle fibers.
为评估治疗性肉毒杆菌毒素注射后人体肌肉的组织学特征，我们研究了11例睑痉挛患者的眼轮匝肌；其中9例曾接受肉毒杆菌毒素注射，2例未接受过。所有肌肉的肌纤维直径变化相当，无坏死、炎症、去神经支配或肌纤维内部结构的持续改变。肉毒杆菌毒素不会在人体肌纤维中产生持续的组织学变化。
