Tsoy E A, Buckley E G, Dutton J J
Am J Ophthalmol. 1985 Feb 15;99(2):176-9. doi: 10.1016/0002-9394(85)90228-4.
In 43 patients (81 eyes) with blepharospasm resistant to other forms of therapy, 149 outpatient injections of botulinum A toxin were given into the orbicularis oculi muscle. Subsequent follow-up periods ranged from ten to 210 days. Orbicularis oculi spasm, eyelid forced closure, and eyebrow spasm all decreased substantially over the first ten days following the initial injection. Patients with essential blepharospasm, hemifacial spasm, or previous surgery all responded in a similar fashion. This beneficial effect was transient, however, and additional treatment was required for sustained relief. Twenty-five patients received multiple injections with a mean interval of 65 days. Results of second and third injections were similar to the first in rapidity of onset and duration of effect. Complications were local, mild, and transient, and no systemic side effects were noted.
在43例（81只眼）对其他治疗形式耐药的睑痉挛患者中，对眼轮匝肌进行了149次门诊肉毒杆菌A毒素注射。随后的随访期为10至210天。在初次注射后的头10天内，眼轮匝肌痉挛、眼睑强迫闭合和眉痉挛均显著减轻。原发性睑痉挛、半面痉挛或既往手术患者的反应相似。然而，这种有益效果是短暂的，需要额外治疗以持续缓解。25例患者接受了多次注射，平均间隔65天。第二次和第三次注射的起效速度和效果持续时间与第一次相似。并发症为局部、轻度且短暂，未观察到全身副作用。
