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绞股蓝能改善非胰岛素依赖型糖尿病大鼠的葡萄糖耐量和组织糖原。

Trichosanthes cucumerina Linn. improves glucose tolerance and tissue glycogen in non insulin dependent diabetes mellitus induced rats.

机构信息

Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), MB Road, Pushp Vihar, Sector-III, New Delhi-110 017, India.

出版信息

Indian J Pharmacol. 2008 Jun;40(3):103-6. doi: 10.4103/0253-7613.42301.

DOI:10.4103/0253-7613.42301
PMID:20040935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2792599/
Abstract

OBJECTIVE

To study the effect of Trichosanthes cucumerina Linn. on non insulin dependent diabetes mellitus induced rats.

MATERIALS AND METHODS

Non Insulin Dependent Diabetes Mellitus (NIDDM) was induced by administering streptozotocin (90 mg/kg, i.p.) in neonatal rat model. NIDDM animals were treated with aqueous extract of Trichosanthes cucumerina (100 mg/kg/day) orally for six weeks. Parameters such as fasting blood glucose, Oral Glucose Tolerance Test (OGTT) and tissue glycogen content were evaluated.

RESULTS

Aqueous extract of Trichosanthes cucumerina significantly (P<0.01) decreased the elevated blood glucose of NIDDM induced rats. OGTT of NIDDM animals showed glucose intolerance. Blood glucose of diabetic animals reached peak at 45 min and remains high even after 2h. In case of Trichosanthes cucumerina treated group, the blood glucose reached peak level at 30 min, followed by decrease in glucose level up to 2h. The drug has significantly (P<0.01) reduced the postprandial blood glucose of diabetic animals. Glycogen content of insulin dependent tissues such as liver and skeletal muscle was found to be improved by 62% and 58.8% respectively with Trichosanthes cucumerina as compared to NIDDM control.

CONCLUSION

Studies revealed that, Trichosanthes cucumerina possess antidiabetic activity. The drug improved the oral glucose tolerance of NIDDM subjects. Increase in tissue glycogen content indicates the effect of the drug on the uptake of glucose by the peripheral tissues to reduce insulin resistance of NIDDM.

摘要

目的

研究黄瓜（Trichosanthes cucumerina Linn.）对非胰岛素依赖型糖尿病（NIDDM）大鼠的作用。

材料与方法

采用链脲佐菌素（90mg/kg，ip）诱导新生大鼠模型，建立非胰岛素依赖型糖尿病（NIDDM）。NIDDM 动物用黄瓜水提取物（100mg/kg/天）口服治疗 6 周。评估空腹血糖、口服葡萄糖耐量试验（OGTT）和组织糖原含量等参数。

结果

黄瓜水提取物显著（P<0.01）降低了 NIDDM 诱导大鼠升高的血糖。NIDDM 动物的 OGTT 显示葡萄糖耐量受损。糖尿病动物的血糖在 45 分钟时达到峰值，即使在 2 小时后仍保持较高水平。在黄瓜处理组中，血糖在 30 分钟时达到峰值，随后在 2 小时内降低血糖水平。该药物显著（P<0.01）降低了糖尿病动物的餐后血糖。与 NIDDM 对照组相比，黄瓜可使依赖胰岛素的组织（如肝和骨骼肌）的糖原含量分别提高 62%和 58.8%。

结论

研究表明，黄瓜具有抗糖尿病活性。该药物改善了 NIDDM 患者的口服葡萄糖耐量。组织糖原含量的增加表明该药物对周围组织摄取葡萄糖的影响，从而降低 NIDDM 的胰岛素抵抗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bafc/2792599/29f386bc8d94/IJPharm-40-103-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bafc/2792599/63103dbe9bae/IJPharm-40-103-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bafc/2792599/7c9706db8e19/IJPharm-40-103-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bafc/2792599/29f386bc8d94/IJPharm-40-103-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bafc/2792599/63103dbe9bae/IJPharm-40-103-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bafc/2792599/7c9706db8e19/IJPharm-40-103-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bafc/2792599/29f386bc8d94/IJPharm-40-103-g003.jpg

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