Ananda Prabu K, Kumarappan C T, Sunil Christudas, Kalaichelvan V K
Department of Pharmacology, Annamalai University, Annamalai Nagar, Chidambaram-608 002, India.
Asian Pac J Trop Biomed. 2012 Jan;2(1):31-5. doi: 10.1016/S2221-1691(11)60185-8.
To investigate the effect of aqueous solution of Biophytum sensitivum leaf extract (BSEt) on normal and streptozotocin (STZ)-nicotinamide-induced diabetic rats.
Diabetes was induced in adult male Wistar rats by the administration of STZ-nicotinamide (40, 110 mg/kg b.w., respectively) intraperitoneally. BSEt (200 mg/kg) was administered to diabetic rats for 28 days. The effect of extract on blood glucose, plasma insulin, total haemoglobin, glycosylated haemoglobin, liver glycogen and carbohydrate metabolism regulating enzymes of liver was studied in diabetic rats.
BSEt significantly reduced the blood glucose and glycosylated haemoglobin levels and significantly increased the total haemoglobin, plasma insulin and liver glycogen levels in diabetic rats. It also increased the hexokinase activity and decreased glucose-6-phosphatase, fructose-1, 6-bisphosphatase activities in diabetic rats.
The results of our study suggest that BSEt possesses a promising effect on STZ-nicotinamide-induced diabetes.
研究含羞草叶提取物水溶液（BSEt）对正常大鼠及链脲佐菌素（STZ）-烟酰胺诱导的糖尿病大鼠的影响。
成年雄性Wistar大鼠腹腔注射STZ-烟酰胺（分别为40、110mg/kg体重）诱导糖尿病。将BSEt（200mg/kg）给予糖尿病大鼠，持续28天。研究提取物对糖尿病大鼠血糖、血浆胰岛素、总血红蛋白、糖化血红蛋白、肝糖原及肝脏碳水化合物代谢调节酶的影响。
BSEt显著降低糖尿病大鼠的血糖和糖化血红蛋白水平，显著提高总血红蛋白、血浆胰岛素和肝糖原水平。它还增加糖尿病大鼠的己糖激酶活性，降低葡萄糖-6-磷酸酶、果糖-1,6-二磷酸酶活性。
我们的研究结果表明，BSEt对STZ-烟酰胺诱导的糖尿病具有显著作用。
