多不饱和脂肪酸与心血管疾病。

Polyunsaturated fatty acids and cardiovascular disease.

机构信息

Department of Critical Care Medicine and Surgery, Unit of Gerontology and Geriatrics, University of Florence and Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

出版信息

Curr Pharm Des. 2009;15(36):4094-102. doi: 10.2174/138161209789909755.

DOI:10.2174/138161209789909755

PMID:20041811

Abstract

Several observational and experimental studies show the beneficial effects of omega-3 poly-unsaturated fatty acids (PUFA) in cardiovascular disease. The results from such studies justify supplementation of omega-3 PUFA in primary and secondary prevention of several clinical conditions, including coronary heart disease, sudden cardiac death and heart failure. Supplementation of omega-3 PUFA is also indicated as monotherapy in the treatment of hypertriglyceridemia. Analysis of their biological actions suggests a variety of anti-arrhythmic, anti-thrombotic, anti-atherosclerotic and anti-inflammatory mechanisms underlying their clinical benefits.

摘要

几项观察性和实验性研究表明 ω-3 多不饱和脂肪酸（PUFA）对心血管疾病有益。这些研究的结果证明了 ω-3 PUFA 在几种临床情况（包括冠心病、心源性猝死和心力衰竭）的一级和二级预防中的补充是合理的。ω-3 PUFA 的补充也被作为单一疗法用于治疗高甘油三酯血症。对其生物学作用的分析表明，其临床益处的基础是多种抗心律失常、抗血栓、抗动脉粥样硬化和抗炎机制。