Department of Metallurgical Engineering and Materials Science, Indian Institute of Technology, Bombay, Mumbai 400 076, India.
Ultrason Sonochem. 2010 Apr;17(4):730-7. doi: 10.1016/j.ultsonch.2009.12.007. Epub 2009 Dec 11.
Materials obtained by the synergistic combination of nanotechnology and biomedicine are an important source of drug delivery and other health care related applications. The anchoring of amino acids onto the surface of nano-sized magnetite is one such example. Herein, we report on the binding of a semi-essential amino acid, L-arginine, onto the surface of nano magnetite, creating a stable aqueous suspension by an in situ one-step method using sonochemical synthesis. An ex situ two-step process was also attempted, but was soon discarded owing to the relative short duration of the suspension attributed to increase in particle size and lower extent of binding. The initial concentration of the amino acid was found to play an important role in controlling the particle size and also the binding motif. Lower concentrations of arginine were found to favor the formation of elongated tubular structures, while at higher concentrations, the elongated structures were less prominent and arginine was found to be adsorbed onto the surface of the magnetite. This surface-functionalized nanomagnetite with amino acids could become a promising vehicle for drug delivery.
通过纳米技术和生物医药协同结合获得的材料是药物输送和其他与健康相关的应用的重要来源。将氨基酸锚定在纳米级磁铁矿的表面就是这样的一个例子。在这里，我们报告了一种半必需氨基酸 L-精氨酸通过原位一步法在超声化学合成的作用下结合到纳米磁铁矿的表面上，从而形成稳定的水悬浮液。我们还尝试了一种外场两步法，但由于悬浮液的持续时间相对较短（归因于颗粒尺寸的增加和结合程度的降低），很快就被摒弃了。发现氨基酸的初始浓度在控制颗粒尺寸和结合模式方面起着重要作用。较低浓度的精氨酸有利于形成细长的管状结构，而在较高浓度下，细长结构不那么明显，精氨酸被发现吸附在磁铁矿的表面上。这种表面功能化的纳米磁铁矿与氨基酸结合，有望成为药物输送的载体。
