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磁性氧化铁纳米颗粒的最新进展：合成、表面功能策略及生物医学应用

Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications.

作者信息

Wu Wei, Wu Zhaohui, Yu Taekyung, Jiang Changzhong, Kim Woo-Sik

机构信息

Department of Chemical Engineering, Kyung Hee University, Korea.

Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, People's Republic of China.

出版信息

Sci Technol Adv Mater. 2015 Apr 28;16(2):023501. doi: 10.1088/1468-6996/16/2/023501. eCollection 2015 Apr.

DOI:10.1088/1468-6996/16/2/023501
PMID:27877761
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5036481/
Abstract

This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical or applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

摘要

本综述聚焦于裸露的和表面功能化的氧化铁纳米颗粒（IONPs）在制备、微观结构和磁性能方面的最新进展及各种策略；还讨论了它们相应的生物学应用。为了实现实际应用，IONPs必须具备高磁饱和度、稳定性、生物相容性以及表面交互功能等综合特性。此外，IONPs的表面可以通过有机材料或无机材料进行修饰，如聚合物、生物分子、二氧化硅、金属等。文中考虑了IONPs合成、表面功能化和生物应用的新功能化策略、问题及主要挑战，以及当前的发展方向。最后，还讨论了这些研究领域的一些未来趋势和前景。

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