Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Semin Diagn Pathol. 2009 Aug;26(3):141-9. doi: 10.1053/j.semdp.2009.10.001.
Postradiation vascular tumors fall into two categories: (1) postradiation cutaneous angiosarcoma, malignant vascular neoplasms with significant morbidity and mortality; and (2) atypical vascular lesions (AVL), vascular tumors that reportedly behave in a benign manner. Postradiation vascular tumors not only present a therapeutic problem for clinicians, but they present an increasingly common diagnostic dilemma for pathologists. Although first described separately 15 years ago, the relationship between postradiation cutaneous angiosarcoma and AVL remains controversial. It appears that, in at least some cases, angiosarcoma can arise in the context of AVL, suggesting that these lesions are part of a spectrum of the same disease process. This latter view point is supported by the significant clinical and histologic overlap found between both tumors. Herein, we will discuss the evolution of this topic while reviewing the various clinical, histopathologic, and prognostic characteristics of postradiation cutaneous angiosarcoma and AVL.
（1）放射性皮肤血管肉瘤，一种具有显著发病率和死亡率的恶性血管肿瘤；（2）非典型血管病变（AVL），据报道这些血管肿瘤表现为良性。放射性血管肿瘤不仅给临床医生带来治疗问题，也给病理学家带来越来越常见的诊断难题。尽管这两种肿瘤在 15 年前就被分别描述，但放射性皮肤血管肉瘤和 AVL 之间的关系仍存在争议。至少在某些情况下，血管肉瘤可能在 AVL 的背景下发生，这表明这些病变是同一疾病过程的一部分。这一观点得到了这两种肿瘤在临床和组织学上存在显著重叠的支持。在此，我们将在讨论这一主题的同时，回顾放射性皮肤血管肉瘤和 AVL 的各种临床、组织病理学和预后特征。
