Division of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona, USA.
Neurosurg Focus. 2010 Jan;28(1):E3. doi: 10.3171/2009.10.FOCUS09207.
MicroRNAs (miRNAs) are now recognized as the primary RNAs involved in the purposeful silencing of the cell's own message. In addition to the established role of miRNAs as developmental regulators of normal cellular function, they have recently been shown to be important players in pathological states such as cancer. The authors review the literature on the role of miRNAs in the formation and propagation of gliomas and medulloblastomas, highlighting the potential of these molecules and their inhibitors as therapeutics.
MicroRNAs (miRNAs) 现已被确认为主要的 RNA，可用于有目的地沉默细胞自身的信息。除了 miRNAs 在正常细胞功能的发育调节中的既定作用外，它们最近还被证明是癌症等病理状态中的重要参与者。作者回顾了 miRNA 在神经胶质瘤和髓母细胞瘤形成和传播中的作用的文献，强调了这些分子及其抑制剂作为治疗剂的潜力。
