Department of Interdisciplinary Social Sciences, University of Utrecht, Heidelberglaan 2, Utrecht, the Netherlands.
Schizophr Bull. 2011 Jul;37(4):850-60. doi: 10.1093/schbul/sbp154. Epub 2009 Dec 31.
The extended psychosis phenotype, or the expression of nonclinical positive psychotic experiences, is already prevalent in adolescence and has a dose-response risk relationship with later psychotic disorder. In 2 large adolescent general population samples (n = 5422 and n = 2230), prevalence and structure of the extended psychosis phenotype was investigated. Positive psychotic experiences, broadly defined, were reported by the majority of adolescents. Exploratory analysis with Structural Equation Modelling (Exploratory Factor Analysis followed by Confirmatory Factor Analysis [CFA]) in sample 1 suggested that psychotic experiences were best represented by 5 underlying dimensions; CFA in sample 2 provided a replication of this model. Dimensions were labeled Hallucinations, Delusions, Paranoia, Grandiosity, and Paranormal beliefs. Prevalences differed strongly, Hallucinations having the lowest and Paranoia having the highest rates. Girls reported more experiences on all dimensions, except Grandiosity, and from age 12 to 16 years rates increased. Hallucinations, Delusions, and Paranoia, but not Grandiosity and Paranormal beliefs, were associated with distress and general measures of psychopathology. Thus, only some of the dimensions of the extended psychosis phenotype in young people may represent a continuum with more severe psychopathology and predict later psychiatric disorder.
扩展的精神病表型,或非临床阳性精神病体验的表达,在青少年中已经很普遍,并且与后来的精神病障碍有剂量反应风险关系。在 2 个大型青少年一般人群样本(n=5422 和 n=2230)中,研究了扩展精神病表型的患病率和结构。大多数青少年报告了广泛定义的阳性精神病体验。在样本 1 中进行的结构方程模型(探索性因素分析后进行验证性因素分析 [CFA])的探索性分析表明,精神病体验最好由 5 个潜在维度来表示;样本 2 中的 CFA 复制了该模型。这些维度分别被标记为幻觉、妄想、偏执、夸大和超自然信仰。患病率差异很大,幻觉的患病率最低,偏执的患病率最高。女孩在除了夸大之外的所有维度上报告的体验更多,并且从 12 岁到 16 岁,患病率增加。幻觉、妄想和偏执,但不是夸大和超自然信仰,与痛苦和一般精神病理学测量有关。因此,年轻人扩展精神病表型的某些维度可能代表与更严重的精神病理学有关的连续体,并预测以后的精神障碍。