在下咽和喉肿瘤进展过程中半乳糖凝集素-8 的上调及其与半乳糖凝集素-1、-3 和-7 的比较。
Galectin-8 up-regulation during hypopharyngeal and laryngeal tumor progression and comparison with galectin-1, -3 and -7.
机构信息
Laboratory of Anatomy, Faculty of Medicine and Pharmacy, University of Mons-Hainaut, Pentagone 1B - Avenue du Champ de Mars, 6, B-7000 Mons, Belgium.
出版信息
Anticancer Res. 2009 Dec;29(12):4933-40.
AIM
To define specific staining patterns for the adhesion/growth-regulatory lectin tandem-repeat-type galectin-8 in hypopharyngeal and laryngeal tumor progression and relate these parameters to galectins 1, 3 and 7 in the quest to explore the galectin network.
MATERIALS AND METHODS
The level of expression of galectin-8 was determined immunohistochemically in a series of 18 and 16 cases of tumor-free epithelium, 24 and 10 cases of low-grade dysplasia, 22 and 15 cases of high-grade dysplasia located in peri-tumoral area of 74 and 37 hypopharyngeal and laryngeal carcinomas.
RESULTS
Marked upregulation in galectin-8 staining intensity and immunopositive area in malignancy versus dysplasia was seen in hypopharyngeal cancer (p<10(-6)), in laryngeal cancer for labeling index and high-grade dysplasia/carcinoma (p<10(-6)). No correlation to recurrence was delineated.
CONCLUSION
The presented data revealed a divergence within the galectin-1, -3, -7 and -8 network during tumor progression.
目的
定义粘附/生长调节凝集素串联重复型半乳糖凝集素-8 在下咽和喉肿瘤进展中的特定染色模式，并将这些参数与半乳糖凝集素 1、3 和 7 相关联，以探索半乳糖凝集素网络。
材料和方法
在 74 例下咽癌和 37 例喉癌的肿瘤周围区域的 24 例和 10 例低级别异型增生、22 例和 15 例高级别异型增生病例中，用免疫组织化学方法测定无肿瘤上皮的 18 例和 16 例、低级别异型增生的 24 例和 10 例中的半乳糖凝集素-8 表达水平。
结果
下咽癌中恶性肿瘤对半乳糖凝集素-8 染色强度和免疫阳性面积的上调明显（p<10(-6)），喉癌中标记指数和高级别异型增生/癌（p<10(-6)）也有上调。未发现与复发有关。
结论
本研究结果表明，在肿瘤进展过程中，半乳糖凝集素-1、-3、-7 和-8 网络存在分歧。
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