Blood Bank, Hospital Sirio Libanês, Rua Adma Jafet 91, São Paulo, 01308-050, Brazil.
Acta Trop. 2010 Jul-Aug;115(1-2):28-34. doi: 10.1016/j.actatropica.2009.12.006. Epub 2010 Jan 4.
Transfusion transmitted Chagas disease was recognized as a medical problem more than 50 years ago. However, little attention was paid to it by Transfusion Medicine, medical authorities or regulatory agencies as a major problem and threat (especially after the advent of HIV/AIDS); perhaps because it was mainly restricted to tropical regions, usually in less developed countries. With the intense human migratory movement from developing to developed countries, it became more common and evident. The scope of this review is to cover the main transfusional aspects of American trypanosomiasis (Chagas disease), including the main strategies to prevent it through donor questionnaires, specific serological testing and alternative methods such as leukofiltration and pathogen reduction procedures, in order to increase the blood safety in both developing and developed countries.
经输血传播的恰加斯病在 50 多年前就被认为是一个医学问题。然而，由于这种疾病主要局限于热带地区，通常在欠发达国家，因此输血医学、医学当局或监管机构对其作为一个主要问题和威胁（尤其是在艾滋病病毒/艾滋病出现之后）几乎没有给予关注。随着发展中国家向发达国家的大规模人口迁移，这种疾病变得更加常见和明显。本次综述的范围涵盖了美洲锥虫病（恰加斯病）的主要输血方面，包括通过献血者问卷、特定的血清学检测以及白细胞滤过和病原体减少处理等替代方法来预防该病的主要策略，以便在发展中国家和发达国家都提高血液安全性。
