Gómez Lina Andrea, Gutierrez Fredy R S, Peñuela Oscar Andres
Biomedical Research Center (CIBUS), School of Medicine, Universidad de la Sabana, Chía, Colombia.
Laboratory of Immunology, School of Medicine, Antonio Nariño University, Bogotá, Colombia.
Hematol Transfus Cell Ther. 2019 Jul-Sep;41(3):262-267. doi: 10.1016/j.htct.2018.12.001. Epub 2019 Mar 21.
Infection by Trypanosoma cruzi is challenging to blood bank supplies in terms of accurate diagnosis, mostly due to its clinical complexity. Infected individuals may remain asymptomatic for years, albeit they may have circulating parasites potentially transferable to eventual receptors of a transfusion.
Although risk donors are systematically excluded through a survey, an important residual risk for transmission remains, evidencing the need to implement additional actions for the detection of T. cruzi in blood banks.
A review of the scientific literature is presented with the objective of identifying relevant publications on this subject.
We discuss the diagnostic considerations of this chronic infection on transfusion medicine and some recent advances in the processing of blood and derivatives units.
Finally, recommendations are made on how the transmission of T. cruzi can be avoided through the implementation of better diagnostic and pathogen control measures at blood banks.
克氏锥虫感染对血库供应而言，在准确诊断方面颇具挑战，主要因其临床复杂性。受感染个体可能多年无症状，尽管他们体内可能存在可转移至最终输血受体的循环寄生虫。
尽管通过调查系统性地排除了风险献血者，但仍存在重要的残余传播风险，这表明有必要在血库实施额外行动以检测克氏锥虫。
对科学文献进行综述，目的是识别关于该主题的相关出版物。
我们讨论了这种慢性感染在输血医学中的诊断考量以及血液和血液制品处理方面的一些最新进展。
最后，就如何通过在血库实施更好的诊断和病原体控制措施来避免克氏锥虫传播提出了建议。
