Department of Chemistry, National Research Lab for Polymer Synthesis and Physics, Center for Electro-Photo Behaviors in Advanced Molecular Systems, Division of Advanced Materials Science, Pohang Accelerator Laboratory, BK School of Molecular Science, and Polymer Research Institute, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
Biomaterials. 2010 Mar;31(9):2517-25. doi: 10.1016/j.biomaterials.2009.12.013. Epub 2010 Jan 4.
New mesoporous silicate-titania resin systems hybridized with 4,5-dihydroxy-m-benzenedisulfonic acid and poly(ethylene glycol)-dimethacrylate component were developed. These inorganic-organic hybrid resins were found to reveal highly controlled ionic and hydrophilic surface with excellent durability and adhesion onto various substrates. The resin films revealed high resistance to nonspecific adsorption of fibrinogen and to adherence by several bacterial pathogens such as Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis. Furthermore, excellent biocompatibility of the developed resins was proved by both HEp-2 cell adhesion in vitro and subcutaneous implantation in mice. The inorganic-organic hybrid resins are strongly promising for biomedical applications including biomedical devices and biosensors.
开发了一种新型的介孔硅钛酸盐树脂体系，该体系与 4,5-二羟基间苯二磺酸和聚乙二醇-二甲基丙烯酸酯组分混合。发现这些无机-有机杂化树脂具有高度可控的离子和亲水性表面，具有优异的耐用性和对各种基底的附着力。树脂膜表现出对纤维蛋白原的非特异性吸附以及对几种细菌病原体（如大肠杆菌、金黄色葡萄球菌、表皮葡萄球菌和粪肠球菌）的粘附具有高抵抗力。此外，开发的树脂的良好生物相容性通过体外 HEp-2 细胞粘附和小鼠皮下植入得到证明。无机-有机杂化树脂在包括生物医学设备和生物传感器在内的生物医学应用中具有广阔的应用前景。
