Department of Stomatology, A.C. Camargo Cancer Hospital, Sao Paulo, Brazil.
Int J Oral Maxillofac Surg. 2010 Feb;39(2):145-9. doi: 10.1016/j.ijom.2009.11.022. Epub 2009 Dec 31.
The aim of this paper is to evaluate the clinical, radiographic, and histopathological findings and treatment modalities in all cases of ameloblastomas treated at the Sao Paulo Cancer Hospital, between 1953 and 2003. 121 case reports were retrieved from the medical files. Data were reviewed and statistical analysis was performed using Kaplan-Meyer method and Cox proportional risk model. The patients' age ranged from 2 to 82 years (mean 33.2 years), with a slight female prevalence. Most cases were located in the posterior mandible (80%). Radiographically, 60% showed a multilocular pattern. 113 casees were solid ameloblastomas, and plexiforme subtype was the most common. Solid tumours were treated by wide resection, curettage and criosurgery, or curettage alone, and unicystic tumours by curettage and/or cryotherapy. The global mean recurrence rate was 22%, with a mean follow-up of 9.7 years. The ameloblastomas were predominantly solid, affecting the posterior mandible. Important factors for outcome were radiographically multilocular lesions, the presence of ruptured basal cortical bone and histologically follicular tumours.
本文旨在评估 1953 年至 2003 年间在圣保罗癌症医院治疗的所有成釉细胞瘤患者的临床、影像学和组织病理学表现及治疗方式。从病历中检索到 121 例病例报告。对数据进行了回顾分析，并采用 Kaplan-Meier 方法和 Cox 比例风险模型进行了统计学分析。患者年龄为 2 至 82 岁（平均 33.2 岁），女性略多于男性。大多数病例位于下颌后区（80%）。影像学上，60%呈多房性表现。113 例为实性成釉细胞瘤，其中以丛状型最常见。实性肿瘤采用广泛切除术、刮除术和冷冻疗法，或单纯刮除术治疗，而单囊型肿瘤采用刮除术和/或冷冻疗法治疗。总的复发率为 22%，平均随访 9.7 年。成釉细胞瘤主要为实性，影响下颌后区。对结果有重要影响的因素包括影像学上的多房性病变、基底部皮质骨破裂以及组织学上的滤泡性肿瘤。
