Division of Biostatistics and Epidemiology, Medical University of South Carolina, SC 29203, USA.
Int J Hyg Environ Health. 2010 Mar;213(2):116-23. doi: 10.1016/j.ijheh.2009.12.004. Epub 2010 Jan 4.
This study was designed to evaluate the association between lead, mercury, and arsenic in the soil near maternal residences during pregnancy and mental retardation or developmental disability (MR/DD) in children. The study was conducted using 6,048 mothers who did not move throughout their pregnancies and lived within six strips of land in South Carolina and were insured by Medicaid between January 1, 1997 and December 31, 2002. The mother child pairs were then followed until June 1, 2008, through their Medicaid reimbursement files, to identify children diagnosed with MR/DD. The soil was sampled for mercury (Hg), lead (Pb), and As based on a uniform grid, and the soil concentrations were Kriged to estimate chemical concentration at individual locations. We identified a significant relationship between MR/DD and As, and the form of the relationship was nonlinear, after controlling for other known risk factors.
本研究旨在评估孕妇住所附近土壤中的铅、汞和砷与儿童智力迟钝或发育障碍（MR/DD）之间的关联。该研究针对的是 6048 名在怀孕期间未搬家且居住在南卡罗来纳州 6 条地带内的母亲，并在 1997 年 1 月 1 日至 2002 年 12 月 31 日期间通过医疗补助计划（Medicaid）获得保险。然后，通过他们的医疗补助报销档案，对母婴对子进行了跟踪，直到 2008 年 6 月 1 日，以确定被诊断为 MR/DD 的儿童。根据统一网格对土壤进行了汞（Hg）、铅（Pb）和砷的采样，并对土壤浓度进行了克里金插值，以估计各个位置的化学浓度。在控制了其他已知的风险因素后，我们发现 MR/DD 与 As 之间存在显著的关系，而且这种关系是非线性的。
