Jiang Meng-Yuan, Zhang Ling, Dong Ze-Jun, Yang Zhu-Liang, Leng Ying, Liu Ji-Kai
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
Chem Pharm Bull (Tokyo). 2010 Jan;58(1):113-6. doi: 10.1248/cpb.58.113.
Three new metabolites, vibralactones D-F (1-3) were isolated from cultures of the basidiomycete Boreostereum vibrans. The relative configuration of 1 was established on the basis of X-ray diffraction analysis, while the absolute configurations of 1-3 were assigned using a modified Mosher's method. Compound 1 showed weak inhibitory activities against isozymes of 11beta-hydroxysteroid dehydrogenases (HSD) with IC(50) values of 85.7 microM (human HSD1), 295.2 microM (mouse HSD1), and 87.1 microM (human HSD2).
从担子菌 Vibrans 的培养物中分离出三种新的代谢产物，即振动内酯 D-F（1-3）。通过 X 射线衍射分析确定了 1 的相对构型，而使用改良的莫舍尔方法确定了 1-3 的绝对构型。化合物 1 对 11β-羟基类固醇脱氢酶（HSD）的同工酶表现出微弱的抑制活性，其 IC(50)值分别为 85.7 μM（人 HSD1）、295.2 μM（小鼠 HSD1）和 87.1 μM（人 HSD2）。
