Sheikh Hassan I, Zakaria Nor Hafizah, Abdul Majid Fadzilah Adibah, Zamzuri Fatihah, Fadhlina Anis, Hairani Muhammad Afnan Shakir
Faculty of Fisheries and Food Science, Universiti Malaysia Terengganu, 21030, Kuala Nerus, Terengganu, Malaysia.
Food Security Research Cluster, Universiti Malaysia Terengganu, 21030, Kuala Nerus, Terengganu, Malaysia.
J Agric Food Res. 2023 Dec;14:100680. doi: 10.1016/j.jafr.2023.100680. Epub 2023 Jun 12.
and are medicinal plants that are commonly used in the form of herbal tea, which is formulated to strengthen the immune system, especially against COVID-19 infection. Excellent antioxidant, anti-inflammatory, and immunostimulatory properties have been reported for their bioactive compounds, which have been shown to aid in stimulating immune systems as well as lowering the risk of severe COVID-19 such as lung injury. Yet, no bibliometric study on the subject is available. Hence, the purpose of this study is to quantitatively examine the existing articles related to the therapeutic potential of these three herbs, as well as their mechanisms of action in combating the SARS-CoV-2 virus. A total of 121 papers were retrieved from Scopus database up to 14 March 2023. The bibliometric analysis was conducted using VOSviewer software. Based on the literature search, was the most researched plant. India appeared as the most prolific country, with the highest number of articles contributed by two authors from India (Rathi, R. and Gayatri Devi, R.). In terms of keywords, the plants were associated with immune modulation, management of symptoms, antioxidant, anti-inflammatory and antiviral activities. Several important bioactive compounds were responsible for these effects such as gingerol, paradol, shogaol, curcumin, calebin A, momordicoside, karaviloside and cucurbitadienol. These compounds were hypothesized to prevent and cure COVID-19 by regulating inflammatory response, downregulating oxidative stress and modulating immunostimulatory activity. This review paper therefore supports the potential of , and to be formulated as a herbal blend for treating and preventing COVID-19 infection.
[植物名称1]和[植物名称2]是常用的药用植物，通常制成草药茶形式，其配方旨在增强免疫系统，特别是抵抗新冠病毒感染。据报道，它们的生物活性化合物具有出色的抗氧化、抗炎和免疫刺激特性，已证明有助于刺激免疫系统，并降低如肺损伤等严重新冠病毒感染的风险。然而，目前尚无关于该主题的文献计量学研究。因此，本研究的目的是定量考察与这三种草药治疗潜力及其对抗新冠病毒机制相关的现有文章。截至2023年3月14日，共从Scopus数据库中检索到121篇论文。使用VOSviewer软件进行文献计量分析。基于文献检索，[植物名称1]是研究最多的植物。印度是发文量最多的国家，印度的两位作者（Rathi, R.和Gayatri Devi, R.）贡献的文章数量最多。在关键词方面，这些植物与免疫调节、症状管理、抗氧化、抗炎和抗病毒活性相关。几种重要的生物活性化合物导致了这些作用，如姜辣素、姜基戊酮、姜烯酚、姜黄素、calebin A、苦瓜苷、karaviloside和葫芦二烯醇。假设这些化合物通过调节炎症反应、下调氧化应激和调节免疫刺激活性来预防和治疗新冠病毒感染。因此，这篇综述文章支持将[植物名称1]、[植物名称2]和[植物名称3]配制成草药混合物用于治疗和预防新冠病毒感染的潜力。 （注：原文中部分植物名称未给出具体内容，用[植物名称1]等代替）
