Morizot D C, Slaugenhaupt S A, Kallman K D, Chakravarti A
University of Texas M.D. Anderson Cancer Center, Science Park, Research Division, Smithville 78957.
Genetics. 1991 Feb;127(2):399-410. doi: 10.1093/genetics/127.2.399.
Analysis of genotypes of 76 polymorphic loci in more than 2600 backcross hybrid individuals derived from intra- and interspecific genetic crosses of fishes of the genus Xiphophorus (Poeciliidae) resulted in the identification of 17 multipoint linkage groups containing 55 protein-coding loci and one sex chromosome-linked pigment pattern gene. Multipoint linkage analyses identified highly probable gene orders for 10 linkage groups. The total genome length was estimated to be approximately 18 Morgans. Comparisons of the Xiphophorus linkage map with those of other fishes, amphibians and mammals suggested that fish gene maps are remarkably similar and probably retain many syntenic groups present in the ancestor of all vertebrates.
对剑尾鱼属（花鳉科）鱼类种内和种间遗传杂交产生的2600多个回交杂种个体中的76个多态性位点进行基因型分析，结果鉴定出17个多点连锁群，其中包含55个蛋白质编码位点和一个性染色体连锁的色素模式基因。多点连锁分析确定了10个连锁群的高度可能的基因顺序。估计基因组总长度约为18摩根。将剑尾鱼的连锁图谱与其他鱼类、两栖动物和哺乳动物的连锁图谱进行比较，结果表明鱼类基因图谱非常相似，可能保留了所有脊椎动物祖先中存在的许多同线群。
