Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.
Cancer. 2010 Apr 15;116(8):2001-10. doi: 10.1002/cncr.24939.
Recent findings indicate that vitamin D obtained from ultraviolet (UV) exposure may reduce the risk of several different cancers. Vitamin D is metabolized to its active form within the kidney, which is the major organ for vitamin D metabolism and activity. Because both the incidence of renal cell carcinoma (RCC) and the prevalence of vitamin D deficiency have increased over the past few decades, in the current study, the authors explored whether occupational UV exposure was associated with RCC risk.
A hospital-based, case-control study of 1097 patients with RCC (cases) and 1476 controls was conducted in 4 Central and Eastern European countries. Demographic and occupational information was collected to examine the association between occupational UV exposure and RCC risk.
A significant reduction (24%-38%) in the risk of RCC was observed with increasing occupational UV exposure among men who participated in the study. No association between UV exposure and RCC risk was observed among women who participated. When the analyses were stratified by latitude as another estimate of sunlight intensity, a stronger reduction (71%-73%) in the risk of RCC was observed between UV exposure and cancer risk among men who resided at the highest latitudes.
The current results suggested that, among men, there is an inverse association between occupational UV exposure and the risk of RCC. Replication studies are warranted to confirm these results.
最近的研究结果表明，通过紫外线（UV）照射获得的维生素 D 可能降低多种不同癌症的风险。维生素 D 在肾脏中代谢为其活性形式，肾脏是维生素 D 代谢和活性的主要器官。由于过去几十年中肾细胞癌（RCC）的发病率和维生素 D 缺乏症的流行率都有所增加，因此在当前的研究中，作者探讨了职业性 UV 暴露是否与 RCC 风险相关。
在 4 个中东欧国家进行了一项基于医院的、针对 1097 名 RCC 患者（病例）和 1476 名对照的病例对照研究。收集了人口统计学和职业信息，以研究职业性 UV 暴露与 RCC 风险之间的关系。
在男性参与者中，随着职业性 UV 暴露的增加，RCC 的风险显著降低（24%-38%）。在女性参与者中，未观察到 UV 暴露与 RCC 风险之间的关联。当根据纬度（作为阳光强度的另一种估计）对分析进行分层时，居住在最高纬度的男性中，UV 暴露与癌症风险之间的风险降低幅度更大（71%-73%）。
目前的结果表明，在男性中，职业性 UV 暴露与 RCC 风险之间存在反比关系。需要进行复制研究来证实这些结果。
