CINBIOSE, Université du Québec à Montréal (UQÀM), C.P. 8888 succ. Centre ville H3C 3P8, Montréal (Québec), Canada.
Environmental Health Research Division, First Nations and Inuit Health Branch, Health Canada, Tunney's Pasture, Ottawa, Ontario K1A 0K9, Canada.
Int J Environ Res Public Health. 2009 Dec;6(12):3179-3189. doi: 10.3390/ijerph6123179. Epub 2009 Dec 11.
This study examined the association between self-reported diabetes, fish consumption and serum levels of organochlorines in a First Nation community. One quarter of the 101 participants reported diabetes. Serum PCBs, but not p,p'-DDE, were positively correlated to consumption frequency of total fish, walleye and pike, but not trout. Reported diabetes was positively associated to p,p'-DDE and some PCB congeners. Odds Ratios (OR) for reported diabetes for those in the upper 75th percentile for serum p,p'-DDE compared to the others were 3.5 (95% CI 1-13.8) and 6.1 (95% CI 1.4-27.3) (weight wet and lipid-standardized values, respectively) and for total sum of PCBs: 4.91 (95% CI 1.4-19.0) and 5.51 (95% CI 1.3-24.1). For participants who were in the upper 50th percentile for trout and white fish intake, reported diabetes was respectively 6 and 4 times lower compared to the others. These findings support the hypothesis that environmental exposure to elevated p,p'-DDE and PCBs is associated with increased risk of diabetes. Consumption of trout and white fish may be beneficial to reduce risk.
本研究考察了一个原住民社区中自我报告的糖尿病、鱼类消费与血清有机氯水平之间的关联。101 名参与者中有四分之一报告患有糖尿病。血清多氯联苯（PCBs），而不是 p,p'-DDE，与总鱼、梭鱼和梭鲈的消费频率呈正相关，但与鳟鱼无关。报告的糖尿病与 p,p'-DDE 和一些 PCB 同系物呈正相关。与其他参与者相比，血清 p,p'-DDE 处于上 75 百分位的参与者报告糖尿病的比值比（OR）分别为 3.5（95%CI 1-13.8）和 6.1（95%CI 1.4-27.3）（湿重和脂质标准化值），而总 PCB 为 4.91（95%CI 1.4-19.0）和 5.51（95%CI 1.3-24.1）。对于摄入鳟鱼和白鱼处于上 50 百分位的参与者，报告的糖尿病分别比其他参与者低 6 倍和 4 倍。这些发现支持了这样一种假设，即环境暴露于高水平的 p,p'-DDE 和多氯联苯与糖尿病风险增加有关。食用鳟鱼和白鱼可能有助于降低风险。
