Chemistry, North Carolina State University, 2620 Yarborough Drive, Raleigh, NC 27695-8204, USA.
Chembiochem. 2010 Feb 15;11(3):396-410. doi: 10.1002/cbic.200900617.
A collection of 2-aminoimidazole/triazole amides has been synthesized and screened for antibiofilm activity. This class of small molecules was found to modulate the biofilm activity of Pseudomonas aeruginosa, a multidrug-resistant strain of Acinetobacter baumannii (MDRAB), a methicillin-resistant Staphylococcus aureus strain (MRSA), Escherichia coli, Rhodospirillum salexigens, Staphylococcus epidermidis, Vibrio vulnificus, and vancomycin-resistant Enterococcus faecium as well as the yeast Candida albicans and Cryptococcus neoformans. Furthermore, lead compounds were found to not lyse red blood cells at active concentrations.
已经合成了一组 2-氨基咪唑/三唑酰胺，并对其进行了抗生物膜活性筛选。这类小分子被发现可以调节铜绿假单胞菌、耐甲氧西林鲍曼不动杆菌（MDRAB）、耐甲氧西林金黄色葡萄球菌（MRSA）、大肠杆菌、盐螺旋菌、表皮葡萄球菌、创伤弧菌和万古霉素耐药粪肠球菌以及白色念珠菌和新生隐球菌等多种微生物的生物膜活性。此外，还发现先导化合物在有效浓度下不会裂解红细胞。
