干细胞研究与治疗的生命伦理学
The bioethics of stem cell research and therapy.
机构信息
Department of Bioethics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106-4976, USA.
出版信息
J Clin Invest. 2010 Jan;120(1):71-5. doi: 10.1172/JCI40435.
Abstract
Discussion of the bioethics of human stem cell research has transitioned from controversies over the source of human embryonic stem cells to concerns about the ethical use of stem cells in basic and clinical research. Key areas in this evolving ethical discourse include the derivation and use of other human embryonic stem cell-like stem cells that have the capacity to differentiate into all types of human tissue and the use of all types of stem cells in clinical research. Each of these issues is discussed as I summarize the past, present, and future bioethical issues in stem cell research.
摘要
关于人类干细胞研究的生物伦理学的讨论已经从对人类胚胎干细胞来源的争议转变为对基础和临床研究中干细胞的伦理使用的关注。这个不断发展的伦理话语的关键领域包括衍生和使用具有分化为所有类型的人类组织的能力的其他人类胚胎样干细胞，以及在临床研究中使用所有类型的干细胞。在总结干细胞研究中过去、现在和未来的生物伦理问题时，我将讨论这些问题中的每一个。
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本文引用的文献
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2
The stem cell research environment: a patchwork of patchworks.干细胞研究环境：拼凑而成的拼凑物。
Stem Cell Rev Rep. 2009 Jun;5(2):82-8. doi: 10.1007/s12015-009-9071-3. Epub 2009 May 27.
3
Obtaining consent for future research with induced pluripotent cells: opportunities and challenges.获取对诱导多能干细胞未来研究的同意：机遇与挑战。
PLoS Biol. 2009 Feb 24;7(2):e42. doi: 10.1371/journal.pbio.1000042.
4
New ISSCR guidelines underscore major principles for responsible translational stem cell research.国际干细胞研究学会（ISSCR）的新指南强调了负责任的转化干细胞研究的主要原则。
Cell Stem Cell. 2008 Dec 4;3(6):607-9. doi: 10.1016/j.stem.2008.11.009.
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Stem cell clinics online: the direct-to-consumer portrayal of stem cell medicine.在线干细胞诊所：干细胞医学面向消费者的宣传
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