Smith Laura A, Liu Xiaohua, Ma Peter X
Department of Biomedical Engineering, University of Michigan, 1011 North University, Ann Arbor, MI 4810 USA.
Soft Matter. 2008 Jan 1;4(11):2144-2149. doi: 10.1039/b807088c.
Tissue Engineering is a rapidly evolving field in terms of cell source and scaffold fabrication. As the template for three dimensional tissue growth, the scaffold should emulate the native extracellular matrix, which is nano-fibrous. Currently, there are three basic techniques capable of generating nano-fibrous scaffolding: electrospinning, molecular self-assembly, and thermally induced phase separation. These scaffolds can then be further modified by various three dimensional surface modification techniques if necessary to more precisely emulate the native extracellular matrix. However, even without further modification, nano-fibrous scaffolds have been shown to have advantageous effects on cellular behavior and tissue formation when compared to more traditional types of scaffolding. This review focuses on the current state of tissue engineering with nano-fibrous scaffolding with particular emphasis on bone tissue engineering.
就细胞来源和支架制造而言，组织工程是一个快速发展的领域。作为三维组织生长的模板，支架应模拟天然的细胞外基质，其是纳米纤维状的。目前，有三种能够生成纳米纤维支架的基本技术：静电纺丝、分子自组装和热致相分离。然后，如果需要，可以通过各种三维表面改性技术对这些支架进行进一步改性，以更精确地模拟天然细胞外基质。然而，与更传统类型的支架相比，即使不进行进一步改性，纳米纤维支架已被证明对细胞行为和组织形成具有有利影响。本综述重点关注纳米纤维支架组织工程的现状，特别强调骨组织工程。
