海洋来源真菌 Cadophora malorum 中羟基化的蛇孢菌素衍生物。
Hydroxylated sclerosporin derivatives from the marine-derived fungus Cadophora malorum.
机构信息
Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
出版信息
J Nat Prod. 2010 Mar 26;73(3):476-8. doi: 10.1021/np900608d.
Abstract
The marine-derived fungus Cadophora malorum was isolated from the green alga Enteromorpha sp. Growth on a biomalt medium supplemented with sea salt yielded an extract, from which we have isolated sclerosporin and four new hydroxylated sclerosporin derivatives, namely, 15-hydroxysclerosporin (2), 12-hydroxysclerosporin (3), 11-hydroxysclerosporin (4), and 8-hydroxysclerosporin (5). The compounds were evaluated in various biological activity assays. Compound 5 showed a weak fat-accumulation inhibitory activity against 3T3-L1 murine adipocytes.
摘要
从绿藻浒苔中分离得到海洋来源的真菌 Cadophora malorum。在添加海水盐的生物麦芽培养基上生长，得到提取物，从中分离出硬皮菌素和四个新的羟基化硬皮菌素衍生物，分别为 15-羟基硬皮菌素（2）、12-羟基硬皮菌素（3）、11-羟基硬皮菌素（4）和 8-羟基硬皮菌素（5）。对这些化合物进行了各种生物活性测定。化合物 5 对 3T3-L1 鼠脂肪细胞的脂肪积累抑制活性较弱。
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