Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Curr Opin Struct Biol. 2010 Feb;20(1):90-7. doi: 10.1016/j.sbi.2009.12.001. Epub 2010 Jan 5.
Virtually all animals and plants utilize small RNA molecules to control protein expression during different developmental stages and in response to viral infection. Structural and mechanistic studies have begun to illuminate three fundamental aspects of these pathways: small RNA biogenesis, formation of RNA-induced silencing complexes (RISCs), and targeting of complementary mRNAs. Here we review exciting recent progress in understanding how regulatory RNAs are produced and how they trigger specific destruction of mRNAs during RNA interference (RNAi).
实际上，所有动植物都利用小分子 RNA 来控制不同发育阶段和应对病毒感染时的蛋白质表达。结构和机制研究已经开始阐明这些途径的三个基本方面：小分子 RNA 的生物发生、RNA 诱导沉默复合物 (RISC) 的形成以及互补 mRNAs 的靶向。在这里，我们回顾了在理解调控 RNA 如何产生以及它们如何在 RNA 干扰 (RNAi) 过程中触发特定的 mRNA 破坏方面的令人兴奋的最新进展。
