Environment Canada, Pacific Environmental Science Centre, British Columbia, Canada.
Environ Health Perspect. 2010 Jan;118(1):1-5. doi: 10.1289/ehp.0900985.
In this commentary we present the findings from an international consortium on fish toxicogenomics sponsored by the U.K. Natural Environment Research Council (Fish Toxicogenomics-Moving into Regulation and Monitoring, held 21-23 April 2008 at the Pacific Environmental Science Centre, Vancouver, BC, Canada).
The consortium from government agencies, academia, and industry addressed three topics: progress in ecotoxicogenomics, regulatory perspectives on roadblocks for practical implementation of toxicogenomics into risk assessment, and dealing with variability in data sets.
Participants noted that examples of successful application of omic technologies have been identified, but critical studies are needed to relate molecular changes to ecological adverse outcome. Participants made recommendations for the management of technical and biological variation. They also stressed the need for enhanced interdisciplinary training and communication as well as considerable investment into the generation and curation of appropriate reference omic data.
The participants concluded that, although there are hurdles to pass on the road to regulatory acceptance, omics technologies are already useful for elucidating modes of action of toxicants and can contribute to the risk assessment process as part of a weight-of-evidence approach.
在这篇评论中，我们呈现了由英国自然环境研究理事会（Fish Toxicogenomics-Moving into Regulation and Monitoring）赞助的一个关于鱼类毒理基因组学的国际研究联盟的研究结果，该联盟于 2008 年 4 月 21 日至 23 日在加拿大温哥华的太平洋环境科学中心举行。
来自政府机构、学术界和工业界的联盟成员讨论了三个主题：生态毒理基因组学的进展、将毒理基因组学实际应用于风险评估的障碍的监管观点，以及处理数据集的变异性。
与会者指出，已经确定了成功应用组学技术的例子，但需要进行关键研究，将分子变化与生态不良后果联系起来。与会者为技术和生物学变异的管理提出了建议。他们还强调需要加强跨学科培训和沟通，以及对适当的参考组学数据的生成和管理进行大量投资。
与会者得出结论，尽管在获得监管部门认可的道路上存在障碍，但组学技术已经可用于阐明毒物的作用模式，并可作为证据权重方法的一部分，为风险评估过程做出贡献。
