Stroke. 2010 Mar;41(3):550-3. doi: 10.1161/STROKEAHA.109.569145. Epub 2010 Jan 7.
Body mass index is most commonly used as the obesity index. Recently, waist circumference (WC) has been shown to be associated with the risk of cardiovascular disease (CVD). However, no studies have observed an association between WC and CVD in Japan. We examined the relationships of WC and body mass index with CVD in a Japanese urban population.
We studied 5474 Japanese individuals (aged 30 to 79 years without CVD at baseline) who completed a baseline survey and received follow-up through December 2005. WC was measured at the umbilical level of participants in the standing position to the nearest 1 cm. The Cox proportional hazard ratios for CVD according to the quartiles of WC were calculated after adjustment for age, smoking, and drinking status.
During a mean follow-up of 11.7 years, 207 strokes and 133 myocardial infarctions were documented. In women, compared with the lowest quartile (WC <70 cm), the hazard ratio (95% CIs) after adjusting for age, smoking, and drinking in the highest quartile (WC >or=84 cm) were 1.85 (1.03 to 3.31) for CVD and 2.64 (1.16 to 6.03) for stroke. However, no such relationships of WC with CVD or stroke risk were observed in men. After further adjustment of hypertension, diabetes, and hypercholesterolemia, all of the mentioned relationships were not statistically significant. No associations of body mass index with CVD or strokes were observed.
WC may be a better predictor for CVD or stroke in Japanese women.
体重指数是最常用于衡量肥胖的指标。最近，腰围（WC）与心血管疾病（CVD）的风险相关。然而，在日本，还没有研究观察到 WC 与 CVD 之间的关联。我们在日本城市人群中研究了 WC 和身体质量指数（BMI）与 CVD 的关系。
我们研究了 5474 名日本个体（基线时无 CVD，年龄 30 至 79 岁），他们完成了基线调查，并随访至 2005 年 12 月。在参与者站立位时，在脐水平测量 WC，精确到 1cm。在调整年龄、吸烟和饮酒状况后，计算 WC 四分位间距与 CVD 的 Cox 比例风险比。
在平均 11.7 年的随访期间，记录了 207 例中风和 133 例心肌梗死。在女性中，与最低四分位数（WC <70cm）相比，最高四分位数（WC ≥84cm）调整年龄、吸烟和饮酒后 CVD 的风险比（95%CI）为 1.85（1.03 至 3.31），中风的风险比为 2.64（1.16 至 6.03）。然而，在男性中，没有观察到 WC 与 CVD 或中风风险的这种关系。在进一步调整高血压、糖尿病和高胆固醇血症后，所有上述关系均无统计学意义。BMI 与 CVD 或中风之间也没有关联。
WC 可能是日本女性 CVD 或中风的更好预测指标。
