手指关节的定量三维光声断层成像：一项活体研究。
Quantitative three-dimensional photoacoustic tomography of the finger joints: an in vivo study.
机构信息
University of Florida, Department of Biomedical Engineering, 130 BME Building, P.O. Box 116131, Gainesville, Florida 32611, USA.
出版信息
J Biomed Opt. 2009 Nov-Dec;14(6):064002. doi: 10.1117/1.3257246.
Abstract
We present for the first time in vivo full three-dimensional (3-D) photoacoustic tomography (PAT) of the distal interphalangeal joint in a human subject. Both absorbed energy density and absorption coefficient images of the joint are quantitatively obtained using our finite-element-based photoacoustic image reconstruction algorithm coupled with the photon diffusion equation. The results show that major anatomical features in the joint along with the side arteries can be imaged with a 1-MHz transducer in a spherical scanning geometry. In addition, the cartilages associated with the joint can be quantitatively differentiated from the phalanx. This in vivo study suggests that the 3-D PAT method described has the potential to be used for early diagnosis of joint diseases such as osteoarthritis and rheumatoid arthritis.
摘要
我们首次在活体中实现了对人手指末节指间关节的全三维（3-D）光声断层成像（PAT）。我们使用基于有限元的光声图像重建算法结合光子扩散方程，定量获得了关节的吸收能量密度和吸收系数图像。结果表明，在球形扫描几何中，1-MHz 换能器可以对关节的主要解剖特征和侧支动脉进行成像。此外，还可以定量区分关节相关的软骨和指骨。这项体内研究表明，所描述的 3-D PAT 方法具有用于早期诊断关节炎等关节疾病（如骨关节炎和类风湿关节炎）的潜力。
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