Università di Bologna, Dipartimento di Scienze Farmaceutiche, Via Belmeloro 6, 40126 Bologna, Italy.
Eur J Med Chem. 2010 Apr;45(4):1374-8. doi: 10.1016/j.ejmech.2009.12.035. Epub 2009 Dec 28.
The reaction between isatin and 2,5-dimethoxyaniline is described. The main product was identified as 3,3-bis(4-amino-2,5-dimethoxyphenyl)-1,3-dihydroindol-2-one. The antioxidant activity of the compounds isolated was evaluated with two methods. Three published antitumor E-3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones entered the same tests to search whether they are endowed with antioxidant activity too. 3,3-Bis(4-amino-2,5-dimethoxyphenyl)-1,3-dihydroindol-2-one and the three antitumor agents showed a good chemical antioxidant activity.
描述了靛红与 2,5-二甲氧基苯胺的反应。主要产物被鉴定为 3,3-双(4-氨基-2,5-二甲氧基苯基)-1,3-二氢吲哚-2-酮。用两种方法评价了分离得到的化合物的抗氧化活性。三种已发表的抗肿瘤 E-3-(2-氯-3-吲哚基亚甲基)-1,3-二氢吲哚-2-酮也进行了相同的测试，以研究它们是否也具有抗氧化活性。3,3-双(4-氨基-2,5-二甲氧基苯基)-1,3-二氢吲哚-2-酮和三种抗肿瘤药物表现出良好的化学抗氧化活性。
