三羧酸循环依赖性合成金黄色葡萄球菌 5 型和 8 型荚膜多糖。
Tricarboxylic acid cycle-dependent synthesis of Staphylococcus aureus Type 5 and 8 capsular polysaccharides.
机构信息
Department of Veterinary and Biomedical Sciences, University of Nebraska, 155 VBS, Fair St. and East Campus Loop, Lincoln, NE 68583-0905, USA.
出版信息
J Bacteriol. 2010 Mar;192(5):1459-62. doi: 10.1128/JB.01377-09. Epub 2010 Jan 8.
Abstract
Staphylococcus aureus capsule synthesis requires the precursor N-acetyl-glucosamine; however, capsule is synthesized during post-exponential growth when the availability of N-acetyl-glucosamine is limited. Capsule biosynthesis also requires aerobic respiration, leading us to hypothesize that capsule synthesis requires tricarboxylic acid cycle intermediates. Consistent with this hypothesis, S. aureus tricarboxylic acid cycle mutants fail to make capsule.
摘要
金黄色葡萄球菌荚膜合成需要前体 N-乙酰葡萄糖胺;然而，荚膜是在指数生长期后合成的，此时 N-乙酰葡萄糖胺的供应是有限的。荚膜生物合成也需要需氧呼吸，这使我们假设荚膜合成需要三羧酸循环中间产物。与这一假设一致，金黄色葡萄球菌三羧酸循环突变体无法合成荚膜。
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