Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, London, United Kingdom.
Mov Disord. 2010 Mar 15;25(4):493-6. doi: 10.1002/mds.22936.
A small proportion of patients with Parkinson's disease (PD) develop a dopamine dysregulation syndrome (DDS). Management of such patients can be difficult; hence, early identification and careful monitoring of at-risk individuals are important. Based on four illustrative cases, we wish to draw attention to the risk of developing DDS in PD patients engaged in a creative and artistic profession, who compulsively abuse dopaminergic drugs to maintain or enhance their artistic creativity. Balancing the drug requirement for treating motor symptoms on one hand and improving creativity on the other hand has to be carefully evaluated and early neuropsychiatric intervention may be necessary. Apart from the known risk factors-young age at PD onset, male gender, heavy alcohol consumption, illegal drug use, and history of affective disorder-engagement in a creative or artistic profession may be an additional risk factor for developing DDS.
一小部分帕金森病（PD）患者会出现多巴胺失调综合征（DDS）。此类患者的治疗可能较为困难；因此，早期识别和仔细监测高危人群非常重要。基于四个案例，我们想提醒从事创造性和艺术性职业的 PD 患者，他们可能会因强迫性滥用多巴胺药物来维持或提高其艺术创造力而出现 DDS 的风险。一方面需要平衡治疗运动症状的药物需求，另一方面需要提高创造力，需要仔细评估，可能需要早期神经心理干预。除了已知的危险因素（PD 发病年龄较早、男性、大量饮酒、使用非法药物和情感障碍病史）外，从事创造性或艺术性职业可能是发生 DDS 的另一个危险因素。
