Department of Microbiology, Kasturba Medical College, Manipal University, Manipal, India.
Int J Dermatol. 2009 Nov;48(11):1198-200. doi: 10.1111/j.1365-4632.2008.04049.x.
Sporotrichosis is commonly encountered due to traumatic implantation of thorns or decayed vegetation with the dimorphic fungi, Sporothrix schenckii. Zoonotic spread of Sporotrichosis is rare and we describe here the first case of feline transmission of lymphocutaneous sporotrichiosis encountered in India.
An excision biopsy of nodulo-ulcerative lesion from the patients right elbow and forearm were collected for histopathology and portion of the specimen processed for mycological work up. Animal pathogenicity test performed in Swiss albino mice with intraperitoneal & foot pad inoculation. In addition an investigation of the ulcerative skin lesion from the domesticated cat was carried out.
Histopathology examination of tissue sample from the patient and feline lesion revealed granulomatous reaction and a few slender elongated yeast cells consistent with Sporotrichosis. The diagnosis was confirmed by culturing Sporothrix schenkii and demonstration of thermal dimorphism. Pathogenicity testing in mice lead to orchitis in 12-15 days and the organism was re-isolated in pure culture. The patient was treated with oral saturated potassium iodide solution with complete resolution of the lesions.
Close contact with infected domesticated feline can be a potential source of transmission for Sporotrichosis as evidenced in this report.
由于创伤性植入荆棘或腐烂植物，双相真菌申克孢子丝菌引起的孢子丝菌病很常见。孢子丝菌病的动物传播很少见，我们在此描述了在印度遇到的首例猫科动物传播的淋巴管皮肤孢子丝菌病。
从患者右肘和前臂的结节溃疡性病变处采集切除活检组织进行组织病理学检查，并对部分标本进行真菌学检查。用腹腔内和足底接种法在瑞士白化小鼠中进行动物致病性试验。此外，对家养猫的溃疡性皮肤病变进行了调查。
对患者和猫的病变组织样本的组织病理学检查显示出肉芽肿反应和少量细长的长形酵母细胞，符合孢子丝菌病。通过培养申克孢子丝菌并证明热二态性，确诊了该疾病。在小鼠中的致病性试验导致 12-15 天的睾丸炎，并在纯培养物中重新分离出该病原体。患者接受了口服饱和碘化钾溶液治疗，病变完全消退。
正如本报告所证明的那样，与受感染的家养猫密切接触可能是孢子丝菌病传播的潜在来源。
