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Immune responses to bovine respiratory syncytial virus (BRSV) following use of an inactivated BRSV-PI3-Mannheimia haemolytica vaccine and a modified live BRSV-BVDV vaccine.使用灭活的牛呼吸道合胞病毒-副流感3型-溶血曼氏杆菌疫苗和改良活牛呼吸道合胞病毒-牛病毒性腹泻病毒疫苗后对牛呼吸道合胞病毒（BRSV）的免疫反应。
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Evaluation of efficacy of an inactivated vaccine against bovine respiratory syncytial virus in calves with maternal antibodies.评估一种灭活疫苗对具有母源抗体的犊牛抗牛呼吸道合胞体病毒的效力。
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Effects of injectable trace minerals on humoral and cell-mediated immune responses to Bovine viral diarrhea virus, Bovine herpes virus 1 and Bovine respiratory syncytial virus following administration of a modified-live virus vaccine in dairy calves.在给奶牛犊牛接种改良活病毒疫苗后，注射用微量矿物质对其针对牛病毒性腹泻病毒、牛疱疹病毒1型和牛呼吸道合胞体病毒的体液免疫和细胞介导免疫反应的影响。
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Inhibition of priming for bovine respiratory syncytial virus-specific protective immune responses following parenteral vaccination of passively immune calves.被动免疫犊牛经肠胃外接种疫苗后，对牛呼吸道合胞体病毒特异性保护性免疫反应启动的抑制作用。
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本文引用的文献

1
Kinetics of antiviral CD8 T cell responses during primary and post-vaccination secondary bovine respiratory syncytial virus infection.初次感染及疫苗接种后二次感染牛呼吸道合胞病毒期间抗病毒CD8 T细胞反应的动力学
Vaccine. 2006 Mar 6;24(10):1551-61. doi: 10.1016/j.vaccine.2005.10.005. Epub 2005 Oct 25.
2
Protection against bovine respiratory syncytial virus challenge following a single dose of vaccine in young calves with maternal antibody.在具有母源抗体的幼龄犊牛中，单剂量疫苗接种后对牛呼吸道合胞病毒攻击的保护作用。
Vet Rec. 2005 Jan 29;156(5):139-43. doi: 10.1136/vr.156.5.139.
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DNA vaccination against respiratory syncytial virus in young calves.针对幼犊进行呼吸道合胞病毒的DNA疫苗接种。
Vaccine. 2005 Jan 26;23(10):1242-50. doi: 10.1016/j.vaccine.2004.09.005.
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Evaluation of a quadrivalent inactivated vaccine for the protection of cattle against diseases due to common viral infections.评估一种四价灭活疫苗对牛的保护作用，以预防常见病毒感染引起的疾病。
J S Afr Vet Assoc. 2004 Sep;75(3):137-46. doi: 10.4102/jsava.v75i3.469.
5
Duration of immunity of a quadrivalent vaccine against respiratory diseases caused by BHV-1, PI3V, BVDV, and BRSV in experimentally infected calves.一种四价疫苗对实验性感染小牛中由牛疱疹病毒1型、副流感病毒3型、牛病毒性腹泻病毒和牛呼吸道合胞体病毒引起的呼吸道疾病的免疫持续时间。
Prev Vet Med. 2004 Dec 15;66(1-4):63-77. doi: 10.1016/j.prevetmed.2004.08.001.
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Bovine respiratory syncytial virus ISCOMs--protection in the presence of maternal antibodies.牛呼吸道合胞病毒免疫刺激复合物——在母源抗体存在情况下的保护作用
Vaccine. 2004 Dec 16;23(5):646-55. doi: 10.1016/j.vaccine.2004.07.006.
7
Immune responses to bovine respiratory syncytial virus (BRSV) following use of an inactivated BRSV-PI3-Mannheimia haemolytica vaccine and a modified live BRSV-BVDV vaccine.使用灭活的牛呼吸道合胞病毒-副流感3型-溶血曼氏杆菌疫苗和改良活牛呼吸道合胞病毒-牛病毒性腹泻病毒疫苗后对牛呼吸道合胞病毒（BRSV）的免疫反应。
Vet J. 2004 Mar;167(2):208-10. doi: 10.1016/S1090-0233(03)00078-9.
8
Vaccine-induced immunopathology during bovine respiratory syncytial virus infection: exploring the parameters of pathogenesis.牛呼吸道合胞病毒感染期间疫苗诱导的免疫病理学：探索发病机制参数
J Virol. 2003 Nov;77(22):12067-73. doi: 10.1128/jvi.77.22.12067-12073.2003.
9
An experimental infection model for reproduction of calf pneumonia with bovine respiratory syncytial virus (BRSV) based on one combined exposure of calves.一种基于犊牛单次联合暴露感染牛呼吸道合胞病毒（BRSV）以引发犊牛肺炎的实验感染模型。
Res Vet Sci. 2003 Feb;74(1):55-65. doi: 10.1016/s0034-5288(02)00154-6.
10
Mucosal immunization with live recombinant bovine respiratory syncytial virus (BRSV) and recombinant BRSV lacking the envelope glycoprotein G protects against challenge with wild-type BRSV.用活重组牛呼吸道合胞病毒（BRSV）和缺乏包膜糖蛋白G的重组BRSV进行黏膜免疫可抵御野生型BRSV的攻击。
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单次接种灭活牛呼吸道合胞病毒疫苗可使具有母源抗体的犊牛产生细胞免疫应答。

A single vaccination with an inactivated bovine respiratory syncytial virus vaccine primes the cellular immune response in calves with maternal antibody.

机构信息

Global Ruminant Business Unit, Intervet International bv, Wim de Körverstraat 35, NL-5831 AN Boxmeer, the Netherlands.

出版信息

BMC Vet Res. 2010 Jan 11;6:2. doi: 10.1186/1746-6148-6-2.

DOI:10.1186/1746-6148-6-2
PMID:20064236
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2824702/
Abstract

BACKGROUND

The efficacy of a single dose of an inactivated bovine respiratory syncytial virus (BRSV)--Parainfluenaza type 3 (PI3)--Mannheimia haemolytica (Mh) combination vaccine, in calves positive for maternal antibodies, was established in a BRSV infection study.

RESULTS

As expected the single vaccination did not have any effect on the decline of BRSV-specific neutralising or ELISA antibody. The cellular immune system was however primed by the vaccination. In the vaccinated group virus excretion with nasal discharge was reduced, less virus could be re-isolated from lung tissues and the lungs were less affected.

CONCLUSIONS

These results indicate that a single vaccination with an inactivated BRSV vaccine was able to break through the maternal immunity and induce partial protection in very young calves. It can be speculated that the level and duration of protection will improve after the second dose of vaccine is administered. A two-dose basic vaccination schedule is recommended under field conditions.

摘要

背景

在牛呼吸道合胞体病毒（BRSV）感染研究中，已证实单剂量的灭活牛呼吸道合胞体病毒（BRSV）-副流感 3 型（PI3）-溶血曼海姆菌（Mh）三联疫苗对具有母源抗体的犊牛有效。

结果

正如预期的那样，单一疫苗接种对 BRSV 特异性中和或 ELISA 抗体的下降没有任何影响。然而，疫苗接种使细胞免疫系统得到了激活。在接种疫苗的组中，鼻分泌物中的病毒排出减少，从肺组织中重新分离出的病毒减少，肺部的影响也较小。

结论

这些结果表明，单次接种灭活的 BRSV 疫苗能够突破母源免疫力，并在非常年幼的犊牛中诱导部分保护。可以推测，在接种第二剂疫苗后，保护水平和持续时间将提高。建议在现场条件下采用两剂基础免疫接种方案。