Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 17177, Sweden.
Cell. 2009 Dec 24;139(7):1220-2. doi: 10.1016/j.cell.2009.12.016.
Understanding how tumor cells invade tissues is key to developing drugs to block metastasis. In this issue, Muller et al. (2009) report that a mutant form of the tumor suppressor p53 in cancer cells boosts the endocytic recycling of the adhesion molecule integrin alpha5beta1 and of epidermal growth factor receptor, promoting invasion and metastasis.
了解肿瘤细胞如何侵袭组织是开发药物阻断转移的关键。在本期中，Muller 等人（2009 年）报告称，癌细胞中肿瘤抑制因子 p53 的一种突变形式增强了黏附分子整合素 α5β1 和表皮生长因子受体的内吞循环，从而促进了侵袭和转移。
