Robottom Bradley J, Shulman Lisa M, Anderson Karen E, Weiner William J
Departments of Neurology and Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
South Med J. 2010 Feb;103(2):178-80. doi: 10.1097/SMJ.0b013e3181ca9b3f.
A case of prolonged encephalopathy and worsened parkinsonism in a Parkinson disease patient exposed to a short course of metoclopramide is described. Parkinson disease (PD) is the second most common neurodegenerative disease in the United States. Because of the increased susceptibility to adverse drug effects, PD presents a special challenge to physicians. Anti-emetic drugs such as metoclopramide are widely used and may be particularly deleterious to PD patients due to blockade of dopamine receptors.
本文描述了一例帕金森病患者在短期使用甲氧氯普胺后出现延长性脑病和帕金森症状加重的病例。帕金森病（PD）是美国第二常见的神经退行性疾病。由于对药物不良反应的易感性增加，PD给医生带来了特殊的挑战。像甲氧氯普胺这样的止吐药物被广泛使用，并且由于多巴胺受体的阻断，可能对PD患者特别有害。
