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研究性抗癌药物三嗪（3-氨基吡啶-2-甲醛缩氨基硫脲）及其锌（II）配合物的荧光性质和细胞分布。

Fluorescence properties and cellular distribution of the investigational anticancer drug triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(II) complex.

机构信息

University of Vienna, Institute of Inorganic Chemistry, Währingerstr. 42, A-1090, Vienna, Austria.

出版信息

Dalton Trans. 2010 Jan 21;39(3):704-6. doi: 10.1039/b919119b. Epub 2009 Oct 22.

DOI:10.1039/b919119b
PMID:20066211
Abstract

Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone), which entered several phase I and II clinical trials as an antitumor chemotherapeutic agent, was found to possess intrinsic fluorescence properties (lambda(ex) = 360 nm), which enabled us to monitor the uptake and intracellular distribution in living human cancer cells by fluorescence microscopy.

摘要

噻嗪（3-氨基吡啶-2-甲醛缩氨基硫脲）作为一种抗肿瘤化疗药物，曾进入过多个 I 期和 II 期临床试验，被发现具有内在的荧光特性（lambda(ex) = 360nm），这使我们能够通过荧光显微镜监测其在活的人类癌细胞中的摄取和细胞内分布。

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