Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Health Qual Life Outcomes. 2011 Mar 15;9:15. doi: 10.1186/1477-7525-9-15.
BACKGROUND/AIM: As Thai people living with HIV/AIDS gain increasing access to antiretroviral (ARV) therapy, it is important to evaluate the impact this has not only on clinical outcomes, but also on patients' functional status and well-being. In this study, we translated, culturally adapted and tested the reliability and validity of two widely-used health-related quality of life questionnaires - the MOS-HIV Health Survey and the SF-12 - in people living with HIV/AIDS in Northern Thailand.
Questionnaires were administered to 100 patients at community hospital outpatient ARV clinics in northern Thailand. Reliability was estimated using Cronbach's alpha, while evidence for validity was tested using known-groups comparison based on CD4 group, symptom distress score, bed days and days of reduced activity in the past three months.
Patients' median age was 36, with 58% female, 58% working as laborers, and 60% completing at least primary education. Median CD4 count was 218 cells/mm3. There were no missing data. For the MOS-HIV and SF-12, mean physical summary scores were 53.1 and 49.0 respectively; mean mental summary scores were 53.4 and 45.6, respectively. Internal consistency coefficients were >0.7 for all but one scale, the PF scale (0.67). As hypothesized, scores were slightly to moderately correlated with CD4 count, symptom score, number of days in bed or with reduced activity. Correlations were higher with physical health scores than with mental health scales. The MOS-HIV discriminated clinical known groups slightly better than the SF-12.
Both the MOS-HIV and the shorter SF-12 were successfully adapted for people with HIV/AIDS in Northern Thailand, and showed encouraging evidence for reliability and validity. These patient reported questionnaires could be valuable tools in evaluating therapeutic interventions and other innovations in health and social services, and to estimate health needs and population disability related to HIV.
背景/目的：随着泰国艾滋病毒/艾滋病感染者越来越多地获得抗逆转录病毒（ARV）治疗，评估这不仅对临床结果，而且对患者的功能状态和幸福感的影响变得非常重要。在这项研究中，我们翻译、文化适应并测试了两种广泛使用的健康相关生活质量问卷——MOS-HIV 健康调查和 SF-12——在泰国北部艾滋病毒感染者中的可靠性和有效性。
在泰国北部的社区医院门诊 ARV 诊所向 100 名患者发放问卷。使用 Cronbach's alpha 估计可靠性，而使用基于 CD4 组、症状困扰评分、过去三个月的卧床天数和活动减少天数的已知组比较来测试有效性的证据。
患者的中位年龄为 36 岁，58%为女性，58%为体力劳动者，60%至少完成了小学教育。中位 CD4 计数为 218 个细胞/mm3。没有缺失数据。对于 MOS-HIV 和 SF-12，身体总分分别为 53.1 和 49.0；精神总分分别为 53.4 和 45.6。除了 PF 量表（0.67）外，所有量表的内部一致性系数均>0.7。如假设的那样，分数与 CD4 计数、症状评分、卧床天数或活动减少天数略有中度相关。与心理健康量表相比，身体健康量表的相关性更高。MOS-HIV 对临床已知组的区分稍好于 SF-12。
MOS-HIV 和较短的 SF-12 都成功地适用于泰国北部的艾滋病毒感染者，并且在可靠性和有效性方面显示出令人鼓舞的证据。这些患者报告问卷可以成为评估治疗干预和健康及社会服务其他创新的有价值的工具，并估计与艾滋病毒相关的健康需求和人口残疾。
